@Article{info:doi/10.2196/12262,
author="Abid, Leila
and Kammoun, Ikram
and Ben Halima, Manel
and Charfeddine, Salma
and Ben Slima, Hedi
and Drissa, Meriem
and Mzoughi, Khadija
and Mbarek, Dorra
and Riahi, Leila
and Antit, Saoussen
and Ben Halima, Afef
and Ouechtati, Wejdene
and Allouche, Emna
and Mechri, Mehdi
and Yousfi, Chedi
and Khorchani, Ali
and Abid, Omar
and Sammoud, Kais
and Ezzaouia, Khaled
and Gtif, Imen
and Ouali, Sana
and Triki, Feten
and Hamdi, Sonia
and Boudiche, Selim
and Chebbi, Marwa
and Hentati, Mouna
and Farah, Amani
and Triki, Habib
and Ghardallou, Houda
and Raddaoui, Haythem
and Zayed, Sofien
and Azaiez, Fares
and Omri, Fadwa
and Zouari, Akram
and Ben Ali, Zine
and Najjar, Aymen
and Thabet, Houssem
and Chaker, Mouna
and Mohamed, Samar
and Chouaieb, Marwa
and Ben Jemaa, Abdelhamid
and Tangour, Haythem
and Kammoun, Yassmine
and Bouhlel, Mahmoud
and Azaiez, Seifeddine
and Letaief, Rim
and Maskhi, Salah
and Amri, Aymen
and Naanaa, Hela
and Othmani, Raoudha
and Chahbani, Iheb
and Zargouni, Houcine
and Abid, Syrine
and Ayari, Mokdad
and ben Ameur, Ines
and Gasmi, Ali
and ben Halima, Nejeh
and Haouala, Habib
and Boughzela, Essia
and Zakhama, Lilia
and ben Youssef, Soraya
and Nasraoui, Wided
and Boujnah, Mohamed Rachid
and Barakett, Nadia
and Kraiem, Sondes
and Drissa, Habiba
and Ben Khalfallah, Ali
and Gamra, Habib
and Kachboura, Salem
and Bezdah, Leila
and Baccar, Hedi
and Milouchi, Sami
and Sdiri, Wissem
and Ben Omrane, Skander
and Abdesselem, Salem
and Kanoun, Alifa
and Hezbri, Karima
and Zannad, Faiez
and Mebazaa, Alexandre
and Kammoun, Samir
and Mourali, Mohamed Sami
and Addad, Faouzi",
title="Design and Rationale of the National Tunisian Registry of Heart Failure (NATURE-HF): Protocol for a Multicenter Registry Study",
journal="JMIR Res Protoc",
year="2021",
month="Oct",
day="27",
volume="10",
number="10",
pages="e12262",
keywords="heart failure; acute heart failure; chronic heart failure; diagnosis; prognosis; treatment",
abstract="Background: The frequency of heart failure (HF) in Tunisia is on the rise and has now become a public health concern. This is mainly due to an aging Tunisian population (Tunisia has one of the oldest populations in Africa as well as the highest life expectancy in the continent) and an increase in coronary artery disease and hypertension. However, no extensive data are available on demographic characteristics, prognosis, and quality of care of patients with HF in Tunisia (nor in North Africa). Objective: The aim of this study was to analyze, follow, and evaluate patients with HF in a large nation-wide multicenter trial. Methods: A total of 1700 patients with HF diagnosed by the investigator will be included in the National Tunisian Registry of Heart Failure study (NATURE-HF). Patients must visit the cardiology clinic 1, 3, and 12 months after study inclusion. This follow-up is provided by the investigator. All data are collected via the DACIMA Clinical Suite web interface. Results: At the end of the study, we will note the occurrence of cardiovascular death (sudden death, coronary artery disease, refractory HF, stroke), death from any cause (cardiovascular and noncardiovascular), and the occurrence of a rehospitalization episode for an HF relapse during the follow-up period. Based on these data, we will evaluate the demographic characteristics of the study patients, the characteristics of pathological antecedents, and symptomatic and clinical features of HF. In addition, we will report the paraclinical examination findings such as the laboratory standard parameters and brain natriuretic peptides, electrocardiogram or 24-hour Holter monitoring, echocardiography, and coronarography. We will also provide a description of the therapeutic environment and therapeutic changes that occur during the 1-year follow-up of patients, adverse events following medical treatment and intervention during the 3- and 12-month follow-up, the evaluation of left ventricular ejection fraction during the 3- and 12-month follow-up, the overall rate of rehospitalization over the 1-year follow-up for an HF relapse, and the rate of rehospitalization during the first 3 months after inclusion into the study. Conclusions: The NATURE-HF study will fill a significant gap in the dynamic landscape of HF care and research. It will provide unique and necessary data on the management and outcomes of patients with HF. This study will yield the largest contemporary longitudinal cohort of patients with HF in Tunisia. Trial Registration: ClinicalTrials.gov NCT03262675; https://clinicaltrials.gov/ct2/show/NCT03262675 International Registered Report Identifier (IRRID): DERR1-10.2196/12262 ",
issn="1929-0748",
doi="10.2196/12262",
url="https://www.researchprotocols.org/2021/10/e12262",
url="https://doi.org/10.2196/12262",
url="http://www.ncbi.nlm.nih.gov/pubmed/34704958"
}