@Article{info:doi/10.2196/11207,
author="McCumber, Micah
and Cain, Demetria
and LeGrand, Sara
and Mayer, Kenneth H
and Murphy, Debra A
and Psioda, Matthew A
and Se{\~{n}}a, Arlene C
and Starks, Tyrel J
and Hudgens, Michael",
title="Adolescent Medicine Trials Network for HIV/AIDS Interventions Data Harmonization: Rationale and Development of Guidelines",
journal="JMIR Res Protoc",
year="2018",
month="Dec",
day="21",
volume="7",
number="12",
pages="e11207",
keywords="adolescent; Adolescent Medicine Trials Network for HIV/AIDS Interventions; data harmonization; HIV",
abstract="Background: The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) research program aims to defeat the rising HIV epidemic among adolescents and young adults in the United States. Objective: This study aims to optimize cross-study analyses and comparisons of standardized measures (variables) collected in the ATN. Methods: Guidelines were developed for harmonizing measures to be collected across ATN studies. Results: Eight domains were identified for harmonization---Demographics and Socioeconomic Characteristics, Sexual Behavior and Risk, Substance Use and Abuse, HIV-Positive Cascade, HIV-Negative Cascade, Mental Health, Social Support and Isolation, and Pre-exposure Prophylaxis Cascade. Conclusions: The collection of selected key measures in a uniform manner across studies facilitates the characterization of participant populations, comparisons between studies, and pooled analysis of data from multiple studies. ",
issn="1929-0748",
doi="10.2196/11207",
url="http://www.researchprotocols.org/2018/12/e11207/",
url="https://doi.org/10.2196/11207",
url="http://www.ncbi.nlm.nih.gov/pubmed/30578242"
}