@Article{info:doi/10.2196/resprot.9839,
author="Wallis, Katharine Ann
and Elley, Carolyn Raina
and Lee, Arier
and Moyes, Simon
and Kerse, Ngaire",
title="Safer Prescribing and Care for the Elderly (SPACE): Protocol of a Cluster Randomized Controlled Trial in Primary Care",
journal="JMIR Res Protoc",
year="2018",
month="Apr",
day="26",
volume="7",
number="4",
pages="e109",
keywords="general practice; safety; prescriptions; multimorbidity; polypharmacy; adverse drug events",
abstract="Background: High-risk prescribing, adverse drug events, and avoidable adverse drug event hospitalizations are common. The single greatest risk factor for high-risk prescribing and adverse drug events is the number of medications a person is taking. More people are living longer and taking more medications for multiple long-term conditions. Most on-going prescribing occurs in primary care. The most effective, cost-effective, and practical approach to safer prescribing in primary care is not yet known. Objective: To test the effect of the Safer Prescribing And Care for the Elderly (SPACE) intervention on high-risk prescribing of nonsteroidal anti-inflammatory and antiplatelet medicines, and related adverse drug event hospitalizations. Methods: This is a protocol of a cluster randomized controlled trial. The clusters will be primary care practices. Data collection and analysis will be at the level of patient. Results: Recruitment started in 2018. Six-month data collection will be in 2018. Conclusions: This study addresses an important translational gap, testing an intervention designed to prompt medicines review and support safer prescribing in routine primary care practice. Trial Registration: Australian New Zealand Clinical Trials Registry: ACTRN12618000034235 http://www.ANZCTR.org.au/ACTRN12618000034235.aspx (Archived with Webcite at http://www.webcitation.org/6yj9RImDf) ",
issn="1929-0748",
doi="10.2196/resprot.9839",
url="http://www.researchprotocols.org/2018/4/e109/",
url="https://doi.org/10.2196/resprot.9839",
url="http://www.ncbi.nlm.nih.gov/pubmed/29699966"
}