%0 Journal Article
%@ 1929-0748
%I JMIR Publications
%V 10
%N 10
%P e32789
%T Understanding Adolescent and Young Adult 6-Mercaptopurine Adherence and mHealth Engagement During Cancer Treatment: Protocol for Ecological Momentary Assessment
%A Psihogios,Alexandra M
%A Rabbi,Mashfiqui
%A Ahmed,Annisa
%A McKelvey,Elise R
%A Li,Yimei
%A Laurenceau,Jean-Philippe
%A Hunger,Stephen P
%A Fleisher,Linda
%A Pai,Ahna LH
%A Schwartz,Lisa A
%A Murphy,Susan A
%A Barakat,Lamia P
%+ Children's Hospital of Philadelphia, University of Pennsylvania, Abramson Pediatric Research Center, Room 1429C, 3615 Civic Center Blvd, Philadelphia, PA, 19104, United States, 1 267 314 0164, psihogiosa@email.chop.edu
%K mHealth
%K ecological momentary assessment
%K adolescents
%K young adults
%K oncology
%K cancer
%K self-management
%K mobile phone
%D 2021
%7 22.10.2021
%9 Protocol
%J JMIR Res Protoc
%G English
%X Background: Adolescents and young adults (AYAs) with cancer demonstrate suboptimal oral chemotherapy adherence, increasing their risk of cancer relapse. It is unclear how everyday time-varying contextual factors (eg, mood) affect their adherence, stalling the development of personalized mobile health (mHealth) interventions. Poor engagement is also a challenge across mHealth trials; an effective adherence intervention must be engaging to promote uptake. Objective: This protocol aims to determine the temporal associations between daily contextual factors and 6-mercaptopurine (6-MP) adherence and explore the proximal impact of various engagement strategies on ecological momentary assessment survey completion. Methods: At the Children’s Hospital of Philadelphia, AYAs with acute lymphoblastic leukemia or lymphoma who are prescribed prolonged maintenance chemotherapy that includes daily oral 6-MP are eligible, along with their matched caregivers. Participants will use an ecological momentary assessment app called ADAPTS (Adherence Assessments and Personalized Timely Support)—a version of an open-source app that was modified for AYAs with cancer through a user-centered process—and complete surveys in bursts over 6 months. Theory-informed engagement strategies will be microrandomized to estimate the causal effects on proximal survey completion. Results: With funding from the National Cancer Institute and institutional review board approval, of the proposed 30 AYA-caregiver dyads, 60% (18/30) have been enrolled; of the 18 enrolled, 15 (83%) have completed the study so far. Conclusions: This protocol represents an important first step toward prescreening tailoring variables and engagement components for a just-in-time adaptive intervention designed to promote both 6-MP adherence and mHealth engagement. International Registered Report Identifier (IRRID): DERR1-10.2196/32789 
%M 34677129
%R 10.2196/32789
%U https://www.researchprotocols.org/2021/10/e32789
%U https://doi.org/10.2196/32789
%U http://www.ncbi.nlm.nih.gov/pubmed/34677129