%0 Journal Article
%@ 1929-0748
%I JMIR Publications
%V 7
%N 12
%P e11207
%T Adolescent Medicine Trials Network for HIV/AIDS Interventions Data Harmonization: Rationale and Development of Guidelines
%A McCumber,Micah
%A Cain,Demetria
%A LeGrand,Sara
%A Mayer,Kenneth H
%A Murphy,Debra A
%A Psioda,Matthew A
%A Seña,Arlene C
%A Starks,Tyrel J
%A Hudgens,Michael
%+ Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, McGavran-Greenberg Hall Campus Box 7420, 135 Dauer Drive, Chapel Hill, NC, 27599, United States, 1 919 966 7253, mhudgens@email.unc.edu
%K adolescent
%K Adolescent Medicine Trials Network for HIV/AIDS Interventions
%K data harmonization
%K HIV
%D 2018
%7 21.12.2018
%9 Original Paper
%J JMIR Res Protoc
%G English
%X Background: The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) research program aims to defeat the rising HIV epidemic among adolescents and young adults in the United States. Objective: This study aims to optimize cross-study analyses and comparisons of standardized measures (variables) collected in the ATN. Methods: Guidelines were developed for harmonizing measures to be collected across ATN studies. Results: Eight domains were identified for harmonization—Demographics and Socioeconomic Characteristics, Sexual Behavior and Risk, Substance Use and Abuse, HIV-Positive Cascade, HIV-Negative Cascade, Mental Health, Social Support and Isolation, and Pre-exposure Prophylaxis Cascade. Conclusions: The collection of selected key measures in a uniform manner across studies facilitates the characterization of participant populations, comparisons between studies, and pooled analysis of data from multiple studies. 
%M 30578242
%R 10.2196/11207
%U http://www.researchprotocols.org/2018/12/e11207/
%U https://doi.org/10.2196/11207
%U http://www.ncbi.nlm.nih.gov/pubmed/30578242