%0 Journal Article
%@ 1929-0748
%I JMIR Publications
%V 7
%N 4
%P e109
%T Safer Prescribing and Care for the Elderly (SPACE): Protocol of a Cluster Randomized Controlled Trial in Primary Care
%A Wallis,Katharine Ann
%A Elley,Carolyn Raina
%A Lee,Arier
%A Moyes,Simon
%A Kerse,Ngaire
%+ Department of General Practice and Primary Health Care, University of Auckland, 261 Morrin Road, Auckland, 1142, New Zealand, 64 9 923 9161, k.wallis@auckland.ac.nz
%K general practice
%K safety
%K prescriptions
%K multimorbidity
%K polypharmacy
%K adverse drug events
%D 2018
%7 26.04.2018
%9 Protocol
%J JMIR Res Protoc
%G English
%X Background: High-risk prescribing, adverse drug events, and avoidable adverse drug event hospitalizations are common. The single greatest risk factor for high-risk prescribing and adverse drug events is the number of medications a person is taking. More people are living longer and taking more medications for multiple long-term conditions. Most on-going prescribing occurs in primary care. The most effective, cost-effective, and practical approach to safer prescribing in primary care is not yet known. Objective: To test the effect of the Safer Prescribing And Care for the Elderly (SPACE) intervention on high-risk prescribing of nonsteroidal anti-inflammatory and antiplatelet medicines, and related adverse drug event hospitalizations. Methods: This is a protocol of a cluster randomized controlled trial. The clusters will be primary care practices. Data collection and analysis will be at the level of patient. Results: Recruitment started in 2018. Six-month data collection will be in 2018. Conclusions: This study addresses an important translational gap, testing an intervention designed to prompt medicines review and support safer prescribing in routine primary care practice. Trial Registration: Australian New Zealand Clinical Trials Registry: ACTRN12618000034235 http://www.ANZCTR.org.au/ACTRN12618000034235.aspx (Archived with Webcite at http://www.webcitation.org/6yj9RImDf) 
%M 29699966
%R 10.2196/resprot.9839
%U http://www.researchprotocols.org/2018/4/e109/
%U https://doi.org/10.2196/resprot.9839
%U http://www.ncbi.nlm.nih.gov/pubmed/29699966