%0 Journal Article
%@ 1929-0748
%I JMIR Publications
%V 8
%N 4
%P e12045
%T The Effect of Vitamin D Supplements on Clinical and Para-Clinical Outcomes in Patients With Multiple Sclerosis: Protocol for a Systematic Review
%A Ghajarzadeh,Mahsa
%A Keshtkar,Abbas Ali
%A Azimi,Amirreza
%A Sahraian,Mohammad Ali
%A Mohammadifar,Mehdi
%A Ramagopalan,Sreeram V
%+ Universal Council of Epidemiology, Universal Scientific Education and Research Network, Tehran University of Medical Sciences, Imam Khomeini Hospital, No 62, Children's Medical Center, Keshavarz Blvd, Dr Mohammad Gharib Avenue, Tehran, 1468763841, Islamic Republic of Iran, 98 9121726995, m.ghajarzadeh@gmail.com
%K multiple sclerosis
%K systematic review
%K relapse
%K magnetic resonance imaging
%K chemokines
%D 2019
%7 22.04.2019
%9 Protocol
%J JMIR Res Protoc
%G English
%X Background: Multiple sclerosis (MS) is an inflammatory disease, which has a wide range of effects on patients. There are controversies regarding the role of vitamin D in clinical and laboratory improvements in MS patients. Objective: The aim of this systematic review protocol is to evaluate the efficacy of vitamin D supplements on relapse rate, gadolinium-enhancing lesions of magnetic resonance imaging (MRI), and cytokine profiles. Methods: We will search PubMed, Scopus, EMBASE, CINAHL, Web of Science, Ovid, ProQuest, American College of Physicians Journal Club database, Health Technology Assessment Database (The Cochrane Collaboration), and National Health System Economic Evaluation Database (The Cochrane Collaboration) and gray literature including reference of included studies and conference abstracts. Clinical trials reporting the effect of any doses of vitamin D on relapse rate, gadolinium-enhancing lesions of MRI, and cytokine profiles will be included. In total, 2 independent researchers will independently assess the studies, extract data, and evaluate the quality of primary studies. Results: This systematic review was started in September 2017 and the process is continuing. The included articles are evaluated and researchers are going to extract the data. Conclusions: To our knowledge, this will be the first comprehensive systematic review aiming to assess the effect of vitamin D supplements on clinical and para-clinical outcomes in patients with multiple sclerosis. International Registered Report Identifier (IRRID): DERR1-10.2196/12045 
%M 31008714
%R 10.2196/12045
%U http://www.researchprotocols.org/2019/4/e12045/
%U https://doi.org/10.2196/12045
%U http://www.ncbi.nlm.nih.gov/pubmed/31008714