%0 Journal Article
%@ 1929-0748
%I JMIR Publications
%V 8
%N 7
%P e14705
%T Acupuncture to Improve Symptoms for Stable Angina: Protocol for a Randomized Controlled Trial
%A Schlaeger,Judith
%A Cai,Hui Yan
%A Steffen,Alana D
%A Angulo,Veronica
%A Shroff,Adhir R
%A Briller,Joan E
%A Hoppensteadt,Debra
%A Uwizeye,Glorieuse
%A Pauls,Heather A
%A Takayama,Miho
%A Yajima,Hiroyoshi
%A Takakura,Nobuari
%A DeVon,Holli A
%+ Department of Women, Children and Family Health Science, College of Nursing, University of Illinois at Chicago, 845 S Damen Avenue, Suite 812, MC 802, Chicago, IL, 60612, United States, 1 3124134669, jschlaeg@uic.edu
%K acupuncture
%K stable angina
%K ischemic heart disease
%K complementary medicine
%D 2019
%7 29.07.2019
%9 Protocol
%J JMIR Res Protoc
%G English
%X Background: Acupuncture has demonstrated physiologic analgesic effects in Chinese patients with stable angina. One proposed mechanism of action for these analgesic effects is the downregulation of M1 macrophages, interleukin 1 beta, interleukin-6, interleukin-18, and tumor necrosis factor alpha. Objective: This study aims to test a 10-session, 5-week acupuncture treatment protocol as a complementary therapy for symptoms of stable angina for American patients, who vary from Chinese patients in health care systems and other salient variables. Methods: We are conducting a randomized controlled trial (RCT) of 69 adults (35 assigned to initial acupuncture and 34 to an attention control condition) with a medically confirmed diagnosis of stable angina, whose pain and associated symptoms have not been controlled to their satisfaction with guideline-directed medical management. Participants in the experimental group will receive a standardized traditional Chinese medicine point prescription. The attention control group will view non–pain-related health education videos over 5 weeks equal to the 10 hours of treatment for the acupuncture group. Participants will complete the McGill Pain Questionnaire and the Seattle Angina Questionnaire-7, as well as have inflammatory cytokines measured at baseline and study completion. The primary outcomes are anginal pain and quality of life. Results: This study has been funded over 2 years by the National Institutes of Health, National Institute for Nursing Research. We are currently recruiting and expect to have initial results by December 2020. Conclusions: We will generate data on feasibility, acceptability, effect sizes, and protocol revisions for a future fully powered RCT of the protocol. Findings will help determine if patients with persistent ischemic symptoms experience a proinflammatory state and hyperalgesia caused by multiple neural and immune processes not always relieved with medication. International Registered Report Identifier (IRRID): DERR1-10.2196/14705 
%M 31359872
%R 10.2196/14705
%U http://www.researchprotocols.org/2019/7/e14705/
%U https://doi.org/10.2196/14705
%U http://www.ncbi.nlm.nih.gov/pubmed/31359872