TY  - JOUR
AU  - Henrique, Patrícia Paula Bazzanello
AU  - Perez, Fabrízzio Martin Pelle
AU  - Becker, Osvaldo Henrique Cemin
AU  - Bellei, Ericles Andrei
AU  - Biduski, Daiana
AU  - Korb, Arthiese
AU  - Pochmann, Daniela
AU  - Dani, Caroline
AU  - Elsner, Viviane Rostirola
AU  - De Marchi, Ana Carolina Bertoletti
PY  - 2021
DA  - 2021/10/13
TI  - Kinesiotherapy With Exergaming as a Potential Modulator of Epigenetic Marks and Clinical Functional Variables of Older Women: Protocol for a Mixed Methods Study
JO  - JMIR Res Protoc
SP  - e32729
VL  - 10
IS  - 10
KW  - elderly women
KW  - exergame
KW  - epigenome
KW  - cognition
KW  - kinesiotherapy
AB  - Background: Kinesiotherapy is an option to mitigate worsening neuropsychomotor function due to human aging. Moreover, exergames are beneficial for the practice of physical therapy by older patients. Physical exercise interventions are known to alter the epigenome, but little is known about their association with exergames. Objective: We aim to evaluate the effects of kinesiotherapy with exergaming on older women’s epigenetic marks and cognitive ability, as well as on their clinical functional variables. Our hypothesis states that this kind of therapy can elicit equal or even better outcomes than conventional therapy. Methods: We will develop a virtual clinic exergame with 8 types of kinesiotherapy exercises. Afterward, we will conduct a 1:1 randomized clinical trial to compare the practice of kinesiotherapy with exergames (intervention group) against conventional kinesiotherapy (control group). A total of 24 older women will be enrolled for 1-hour sessions performed twice a week, for 6 weeks, totaling 12 sessions. We will assess outcomes using epigenetic blood tests, the Montreal Cognitive Assessment test, the Timed Up and Go test, muscle strength grading in a hydraulic dynamometer, and the Game Experience Questionnaire at various stages. Results: The project was funded in October 2019. Game development took place in 2020. Patient recruitment and a clinical trial are planned for 2021. Conclusions: Research on this topic is likely to significantly expand the understanding of kinesiotherapy and the impact of exergames. To the best of our knowledge, this may be one of the first studies exploring epigenetic outcomes of exergaming interventions. Trial Registration: Brazilian Clinical Trials Registry/Registro Brasileiro de Ensaios Clínicos (ReBEC) RBR-9tdrmw; https://ensaiosclinicos.gov.br/rg/RBR-9tdrmw. International Registered Report Identifier (IRRID): DERR1-10.2196/32729 
SN  - 1929-0748
UR  - https://www.researchprotocols.org/2021/10/e32729
UR  - https://doi.org/10.2196/32729
UR  - http://www.ncbi.nlm.nih.gov/pubmed/34643543
DO  - 10.2196/32729
ID  - info:doi/10.2196/32729
ER  -