TY  - JOUR
AU  - Mikuteit, Marie
AU  - Heinemann, Stephanie
AU  - Roder, Sascha
AU  - Niewolik, Jacqueline
AU  - Schröder, Dominik
AU  - Vahldiek, Kai
AU  - Klawitter, Sandra
AU  - Cossmann, Anne
AU  - Bergemann, Torsten
AU  - Degen, Chantal
AU  - Klawonn, Frank
AU  - Behrens, Georg Martin Norbert
AU  - Müller, Frank
AU  - Dopfer-Jablonka, Alexandra
AU  - Steffens, Sandra
PY  - 2022
DA  - 2022/10/26
TI  - Long-term Consequences of COVID-19 and the Pandemic: Protocol for a Web-Based, Longitudinal Observational Study (DEFEAT)
JO  - JMIR Res Protoc
SP  - e38718
VL  - 11
IS  - 10
KW  - SARS-CoV-2
KW  - COVID-19
KW  - long COVID
KW  - post–COVID-19
KW  - long haulers
KW  - pandemic
KW  - long-term effects
KW  - symptoms
KW  - long-term
KW  - risk factors
KW  - Germany
KW  - population study
KW  - quality of life
KW  - social participation
KW  - engagement
AB  - Background: With population-wide vaccination availability, the global COVID-19 pandemic entered a new phase. Despite vaccination status, some people who were infected with SARS-CoV-2 experience long-term symptoms. Objective: In this study, we aim to characterize the long-term effects of SARS-CoV-2 infection and the pandemic. We also aim to build symptom clusters and determine risk factors for developing long COVID symptoms. Furthermore, we assess social participation and health-related quality of life in patients with long COVID and in the general population during a global pandemic. Methods: With a mixed-methods, web-based approach, we aim to recruit 2000 people in Germany who are older than 18 years and can provide informed consent. In the quantitative arm of the study, we identify symptoms of and predictive factors for long COVID manifestations with cluster analysis and assess social participation during the pandemic with standardized questionnaires. The qualitative arm of the study uses individual interviews and focus group discussions to better understand the illness experience of persons who experience long COVID. Results: Recruitment started in September 2021. Up until July 2022, we recruited approximately 4500 participants via our web-based database. Conclusions: This study aims to build an innovative, patient-centered, web-based research platform appropriate for the pandemic by minimizing physical contact between study personnel and participants. All study activities are designed to better understand the long COVID syndrome, social participation during the pandemic, and the illness experiences of persons affected by long COVID. Trial Registration: German Clinical Trial Registry DRKS00026007; https://tinyurl.com/yh282fkt International Registered Report Identifier (IRRID): DERR1-10.2196/38718 
SN  - 1929-0748
UR  - https://www.researchprotocols.org/2022/10/e38718
UR  - https://doi.org/10.2196/38718
UR  - http://www.ncbi.nlm.nih.gov/pubmed/36108134
DO  - 10.2196/38718
ID  - info:doi/10.2196/38718
ER  -