TY  - JOUR
AU  - Holm, Tanja Fredensborg
AU  - Udsen, Flemming Witt
AU  - Færch, Kristine
AU  - Jensen, Morten Hasselstrøm
AU  - von Scholten, Bernt Johan
AU  - Hejlesen, Ole Kristian
AU  - Hangaard, Stine
PY  - 2024
DA  - 2024/2/9
TI  - The Effectiveness of Digital Health Lifestyle Interventions on People With Prediabetes: Protocol for a Systematic Review, Meta-Analysis, and Meta-Regression
JO  - JMIR Res Protoc
SP  - e50340
VL  - 13
KW  - digital health
KW  - effectiveness
KW  - lifestyle intervention
KW  - meta-analysis
KW  - meta-regression
KW  - prediabetic state
KW  - systematic review
KW  - type 2 diabetes prevention
KW  - weight loss
AB  - Background: There has been an increasing interest in the use of digital health lifestyle interventions for people with prediabetes, as these interventions may offer a scalable approach to preventing type 2 diabetes. Previous systematic reviews on digital health lifestyle interventions for people with prediabetes had limitations, such as a narrow focus on certain types of interventions, a lack of statistical pooling, and no broader subgroup analysis of intervention characteristics. The identified limitations observed in previous systematic reviews substantiate the necessity of conducting a comprehensive review to address these gaps within the field. This will enable a comprehensive understanding of the effectiveness of digital health lifestyle interventions for people with prediabetes. Objective: The objective of this systematic review, meta-analysis, and meta-regression is to systematically investigate the effectiveness of digital health lifestyle interventions on prediabetes-related outcomes in comparison with any comparator without a digital component among adults with prediabetes. Methods: This systematic review will include randomized controlled trials that investigate the effectiveness of digital health lifestyle interventions on adults (aged 18 years or older) with prediabetes and compare the digital interventions with nondigital interventions. The primary outcome will be change in body weight (kg). Secondary outcomes include, among others, change in glycemic status, markers of cardiometabolic health, feasibility outcomes, and incidence of type 2 diabetes. Embase, PubMed, CINAHL, and CENTRAL (Cochrane Central Register of Controlled Trials) will be systematically searched. The data items to be extracted include study characteristics, participant characteristics, intervention characteristics, and relevant outcomes. To estimate the overall effect size, a meta-analysis will be conducted using the mean difference. Additionally, if feasible, meta-regression on study, intervention, and participant characteristics will be performed. The Cochrane risk of bias tool will be applied to assess study quality, and the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach will be used to assess the certainty of evidence. Results: The results are projected to yield an overall estimate of the effectiveness of digital health lifestyle interventions on adults with prediabetes and elucidate the characteristics that contribute to their effectiveness. Conclusions: The insights gained from this study may help clarify the potential of digital health lifestyle interventions for people with prediabetes and guide the decision-making regarding future intervention components. Trial Registration: PROSPERO CRD42023426919; http://tinyurl.com/d3enrw9j International Registered Report Identifier (IRRID): PRR1-10.2196/50340 
SN  - 1929-0748
UR  - https://www.researchprotocols.org/2024/1/e50340
UR  - https://doi.org/10.2196/50340
UR  - http://www.ncbi.nlm.nih.gov/pubmed/38335018
DO  - 10.2196/50340
ID  - info:doi/10.2196/50340
ER  -