TY  - JOUR
AU  - Gabb, Victoria Grace
AU  - Blackman, Jonathan
AU  - Morrison, Hamish Duncan
AU  - Biswas, Bijetri
AU  - Li, Haoxuan
AU  - Turner, Nicholas
AU  - Russell, Georgina M
AU  - Greenwood, Rosemary
AU  - Jolly, Amy
AU  - Trender, William
AU  - Hampshire, Adam
AU  - Whone, Alan
AU  - Coulthard, Elizabeth
PY  - 2024
DA  - 2024/3/22
TI  - Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study
JO  - JMIR Res Protoc
SP  - e52652
VL  - 13
KW  - feasibility
KW  - sleep
KW  - mild cognitive impairment
KW  - dementia
KW  - Lewy body disease
KW  - Alzheimer disease
KW  - Parkinson
KW  - wearable devices
KW  - research
KW  - mobile phone
KW  - electroencephalography
KW  - accelerometery
KW  - mobile applications
KW  - application
KW  - app
KW  - cognitive
KW  - cognitive impairment
KW  - sleeping
KW  - sleep disturbance
KW  - risk factor
KW  - Alzheimer
KW  - wearable
KW  - wearables
KW  - acceptability
KW  - smart device
AB  - Background: Sleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population. Objective: This study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD. Methods: We will deliver a feasibility and acceptability study alongside a prospective observational cohort study assessing sleep and cognition longitudinally in the home environment. Adults aged older than 50 years who were diagnosed with mild to moderate dementia or mild cognitive impairment (MCI) due to probable AD or LBD and age-matched controls will be eligible. Exclusion criteria include lack of capacity to consent to research, other causes of MCI or dementia, and clinically significant sleep disorders. Participants will complete a cognitive assessment and questionnaires with a researcher and receive training and instructions for at-home study tasks across 8 weeks. At-home study tasks include remote sleep assessments using wearable devices (electroencephalography headband and actigraphy watch), app-based sleep diaries, online cognitive assessments, and saliva samples for melatonin- and cortisol-derived circadian markers. Feasibility outcomes will be assessed relating to recruitment and retention, data completeness, data quality, and support required. Feedback on acceptability and usability will be collected throughout the study period and end-of-study interviews will be analyzed using thematic analysis. Results: Recruitment started in February 2022. Data collection is ongoing, with final data expected in February 2024 and data analysis and publication of findings scheduled for the summer of 2024. Conclusions: This study will allow us to assess if remote testing using smart devices and wearable technology is a viable alternative to traditional sleep measurements, such as polysomnography and questionnaires, in older adults with and without MCI or dementia due to AD or LBD. Understanding participant experience and the barriers and facilitators to technology use for research purposes and remote research in this population will assist with the development of, recruitment to, and retention within future research projects studying sleep and cognition outside of the clinic or laboratory. International Registered Report Identifier (IRRID): DERR1-10.2196/52652 
SN  - 1929-0748
UR  - https://www.researchprotocols.org/2024/1/e52652
UR  - https://doi.org/10.2196/52652
UR  - http://www.ncbi.nlm.nih.gov/pubmed/38517469
DO  - 10.2196/52652
ID  - info:doi/10.2196/52652
ER  -