TY  - JOUR
AU  - Jerome, Gerald J
AU  - Appel, Lawrence J
AU  - Bunyard, Linda
AU  - Dalcin, Arlene T
AU  - Durkin, Nowella
AU  - Charleston, Jeanne B
AU  - Kanarek, Norma F
AU  - Carducci, Michael A
AU  - Wang, Nae-Yuh
AU  - Yeh, Hsin-Chieh
PY  - 2024
DA  - 2024/6/12
TI  - Behavioral Weight Loss Programs for Cancer Survivors Throughout Maryland: Protocol for a Pragmatic Trial and Participant Characteristics
JO  - JMIR Res Protoc
SP  - e54126
VL  - 13
KW  - cancer
KW  - obesity
KW  - weight loss
KW  - pragmatic trial
KW  - oncology
KW  - weight
KW  - overweight
KW  - obese
KW  - USA
KW  - United States
KW  - survivor
KW  - survivors
KW  - remote
KW  - self-directed
KW  - self-guided
KW  - coach
KW  - coaching
KW  - mHealth
KW  - mobile health
KW  - app
KW  - apps
KW  - application
KW  - applications
KW  - EHR
KW  - health record
KW  - health records
KW  - mobile phone
AB  - Background: Clinical trials examining lifestyle interventions for weight loss in cancer survivors have been demonstrated to be safe, feasible, and effective. However, scalable weight loss programs are needed to support their widespread implementation. The ASPIRE trial was designed to evaluate real-world, lifestyle-based, weight loss programs for cancer survivors throughout Maryland. Objective: The objectives of this protocol paper are to describe the design of a nonrandomized pragmatic trial, study recruitment, and baseline characteristics of participants. Methods: Participants were aged ≥18 years, residing in Maryland, with a BMI ≥25 kg/m2, who reported a diagnosis of a malignant solid tumor, completed curative treatment, and had no ongoing or planned cancer treatment. Enrollment criteria were minimized to increase generalizability. The primary recruitment source was the Johns Hopkins Health System electronic health records (EHRs). Participants selected 1 of 3 remotely delivered weight loss programs: self-directed, app-supported, or coach-supported program. Results: Participants were recruited across all 5 geographic regions of Maryland. Targeted invitations using EHRs accounted for 287 (84.4%) of the 340 participants enrolled. Of the 5644 patients invited through EHR, 5.1% (287/5644) enrolled. Participants had a mean age of 60.7 (SD 10.8) years, 74.7% (254/340) were female, 55.9% (190/340) identified as non-Hispanic Black, 58.5% (199/340) had a bachelor’s degree, and the average BMI was 34.1 kg/m2 (SD 5.9 kg/m2). The most common types of cancers were breast (168/340, 49.4%), prostate (72/340, 21.2%), and thyroid (39/340, 8.5%). The self-directed weight loss program (n=91) included 25 participants who agreed to provide weights through a study scale; the app-supported program (n=142) included 108 individuals who agreed to provide their weight measurements; and the coach-supported weight loss program included 107 participants. We anticipate final analysis will take place in the fall of 2024. Conclusions: Using EHR-based recruitment efforts, this study took a pragmatic approach to reach and enroll cancer survivors into remotely delivered weight loss programs. Trial Registration: ClinicalTrials.gov NCT04534309; https://clinicaltrials.gov/study/NCT04534309 International Registered Report Identifier (IRRID): DERR1-10.2196/54126 
SN  - 1929-0748
UR  - https://www.researchprotocols.org/2024/1/e54126
UR  - https://doi.org/10.2196/54126
UR  - http://www.ncbi.nlm.nih.gov/pubmed/38865181
DO  - 10.2196/54126
ID  - info:doi/10.2196/54126
ER  -