TY - JOUR AU - Schnitzspahn, Katharina AU - Abdulla, Kahar AU - Arensman, Ella AU - Van Audenhove, Chantal AU - Mere, Rainer AU - Pérez Sola, Victor AU - Sisask, Merike AU - Székely, András AU - Toczyski, Piotr AU - Hegerl, Ulrich PY - 2025 DA - 2025/1/10 TI - Community-Based 4-Level Intervention Targeting Depression and Suicidal Behavior in Europe: Protocol for an Implementation Project JO - JMIR Res Protoc SP - e64218 VL - 14 KW - depression KW - suicide KW - mental health KW - European Alliance Against Depression KW - EAAD KW - 4-level community-based intervention KW - iFightDepression KW - cognitive behavioral therapy KW - mHealth AB - Background: The community-based, 4-level intervention of the European Alliance Against Depression (EAAD) is simultaneously addressing depression and suicidal behavior. Intervention activities target primary care health professionals (level 1), the general public (level 2), community facilitators (level 3), and patients and their relatives (level 4). Activities comprise the digital iFightDepression tool, a guided self-management tool based on cognitive behavioral therapy. Objective: This study aimed to present the European Union–cofunded EAAD-Best study protocol, aiming at the implementation, dissemination, and evaluation of the 4-level intervention and the iFightDepression tool in several countries across Europe. Methods: The 4-level intervention has been implemented for the first time in Bulgaria, Estonia, Greece, and Poland. In 3 countries that have already implemented the 4-level intervention (Hungary, Ireland, and Spain), activities have been extended to new regions. In addition, the nationwide uptake of the iFightDepression tool by patients with depression has been promoted in all mentioned countries and Italy. Results: To evaluate the implementation of the 4-level intervention and the iFightDepression tool, data related to the process, output, and outcome were collected between 2022 and 2024. Data processing and analyses started in 2023. Analyses are expected to be completed in 2024. Results are expected to be published in 2025. Conclusions: This paper informs researchers, practitioners, and stakeholders on how to implement best practices in mental health promotion and evaluate their effectiveness. International Registered Report Identifier (IRRID): DERR1-10.2196/64218 SN - 1929-0748 UR - https://www.researchprotocols.org/2025/1/e64218 UR - https://doi.org/10.2196/64218 DO - 10.2196/64218 ID - info:doi/10.2196/64218 ER -