TY  - JOUR
AU  - Hess, Lisa M
AU  - Kern, David M
AU  - Carter, Gebra Cuyun
AU  - Wang, Liya
AU  - Winfree, Katherine
AU  - Cui, Zhanglin Lin
AU  - Sontag, Angelina
AU  - Oton, Ana B
PY  - 2017
DA  - 2017/10/11
TI  - Real-World Treatment Sequences and Outcomes Among Patients With Non-Small Cell Lung Cancer (RESOUNDS) in the United States: Study Protocol
JO  - JMIR Res Protoc
SP  - e195
VL  - 6
IS  - 10
KW  - cancer
KW  - non-small cell lung cancer
KW  - chemotherapy
KW  - regimen
KW  - line of therapy
KW  - treatment sequence
KW  - progression-free survival
KW  - overall survival
KW  - real-world data
AB  - Background: Survival outcomes are related to treatment choices in a line of therapy and to treatment sequences across all lines of therapy. Objective: The Real-World Treatment Sequences and Outcomes among Patients with NSCLC (RESOUNDS) study is designed to (1) evaluate treatment sequences used for patients who receive at least two lines of therapy for non-small cell lung cancer (NSCLC) in the United States and (2) evaluate patient outcomes in terms of progression-free and overall survival related to treatment sequencing. Additional objectives include the evaluation of symptoms, comorbidities, and health care resource utilization and costs. Methods: Patients will be censored at loss to follow-up due to leaving the health plan or reaching the end of the study period. Results: This study is ongoing. Conclusions: The RESOUNDS cohort study is a novel approach to building a comprehensive dataset that mimics a prospective observational study using linked patient-level data from four real-world data sources. This study will provide timely information on the sequencing of treatments for patients with NSCLC. 
SN  - 1929-0748
UR  - http://www.researchprotocols.org/2017/10/e195/
UR  - https://doi.org/10.2196/resprot.7750
DO  - 10.2196/resprot.7750
ID  - info:doi/10.2196/resprot.7750
ER  -