TY  - JOUR
AU  - McCumber, Micah
AU  - Cain, Demetria
AU  - LeGrand, Sara
AU  - Mayer, Kenneth H
AU  - Murphy, Debra A
AU  - Psioda, Matthew A
AU  - Seña, Arlene C
AU  - Starks, Tyrel J
AU  - Hudgens, Michael
PY  - 2018
DA  - 2018/12/21
TI  - Adolescent Medicine Trials Network for HIV/AIDS Interventions Data Harmonization: Rationale and Development of Guidelines
JO  - JMIR Res Protoc
SP  - e11207
VL  - 7
IS  - 12
KW  - adolescent
KW  - Adolescent Medicine Trials Network for HIV/AIDS Interventions
KW  - data harmonization
KW  - HIV
AB  - Background: The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) research program aims to defeat the rising HIV epidemic among adolescents and young adults in the United States. Objective: This study aims to optimize cross-study analyses and comparisons of standardized measures (variables) collected in the ATN. Methods: Guidelines were developed for harmonizing measures to be collected across ATN studies. Results: Eight domains were identified for harmonization—Demographics and Socioeconomic Characteristics, Sexual Behavior and Risk, Substance Use and Abuse, HIV-Positive Cascade, HIV-Negative Cascade, Mental Health, Social Support and Isolation, and Pre-exposure Prophylaxis Cascade. Conclusions: The collection of selected key measures in a uniform manner across studies facilitates the characterization of participant populations, comparisons between studies, and pooled analysis of data from multiple studies. 
SN  - 1929-0748
UR  - http://www.researchprotocols.org/2018/12/e11207/
UR  - https://doi.org/10.2196/11207
UR  - http://www.ncbi.nlm.nih.gov/pubmed/30578242
DO  - 10.2196/11207
ID  - info:doi/10.2196/11207
ER  -