TY  - JOUR
AU  - Hernández-Gallego, Jesús
AU  - Llamas-Velasco, Sara
AU  - Bermejo-Pareja, Felix
AU  - Vega, Saturio
AU  - Tapias-Merino, Ester
AU  - Rodríguez-Sánchez, Emiliano
AU  - Boycheva, Elina
AU  - Serrano, José Ignacio
AU  - Gil-García, Juan-Francisco
AU  - Trincado, Rocio
AU  - Sánchez-Rodrigo, José-María Vizcaino
AU  - Cacho, Jesús
AU  - Contador, Israel
AU  - Garcia-Ptacek, Sara
AU  - Sierra-Hidalgo, Fernando
AU  - Cubo, Esther
AU  - Carro, Eva
AU  - Villarejo-Galende, Alberto
AU  - García García-Patino, Rosalía
AU  - Benito-León, Julián
PY  - 2019
DA  - 2019/01/10
TI  - Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study
JO  - JMIR Res Protoc
SP  - e10941
VL  - 8
IS  - 1
KW  - dementia
KW  - essential tremor
KW  - headache
KW  - longitudinal study
KW  - mild cognitive impairment
KW  - NEDICES
KW  - observational study
KW  - Parkinson’s disease
KW  - pilot study
KW  - population-based study
KW  - stroke
AB  - Background: The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. Objective: The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. Methods: A selection of patients and participants of the planned NEDICES-2 underwent face-to-face interviews including a comprehensive questionnaire on demographics, current medications, medical conditions, and lifestyle habits. Biological samples (blood, saliva, urine, and hair) were also obtained. Furthermore, every participant was examined by a neurologist. Results: In this pilot study, 567 study participants were enrolled (196 from hospitals and 371 from primary care physician lists). Of these 567, 310 completed all study procedures (questionnaires and the neurological evaluation). The study was time-consuming for several primary care physicians. Hence, a few primary care physicians from some areas refused to participate, which led to a reconfiguration of study areas. In addition, the central biobank needed to be supplemented by the biobanks of local Spanish National Health System hospitals. Conclusions: Population-based epidemiological surveys, such as the NEDICES-2, require a pilot study to evaluate the feasibility of all aspects of a future field study (population selection, methods and instruments to be used, neurological diagnosis agreement, and data collection). 
SN  - 1929-0748
UR  - http://www.researchprotocols.org/2019/1/e10941/
UR  - https://doi.org/10.2196/10941
UR  - http://www.ncbi.nlm.nih.gov/pubmed/30632964
DO  - 10.2196/10941
ID  - info:doi/10.2196/10941
ER  -