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Accepted for/Published in: JMIR Research Protocols

Date Submitted: Jan 16, 2020
Open Peer Review Period: Jan 16, 2020 - Feb 17, 2020
Date Accepted: Mar 20, 2020
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Development of a Short Instrument for Measuring Health-Related Quality of Life in Oncological Patients for Clinical Use: Protocol for an Observational Study

Schrage T, Görlach M, Betz CS, Bokemeyer C, Kroeger N, Mueller V, Petersen C, Krüll A, Bleich C, Schulz H

Development of a Short Instrument for Measuring Health-Related Quality of Life in Oncological Patients for Clinical Use: Protocol for an Observational Study

JMIR Res Protoc 2020;9(7):e17854

DOI: 10.2196/17854

PMID: 32726289

PMCID: 7424483

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Development of a short instrument for measuring health related quality of life in oncological patients for the use in clinical routine – observational study protocol

  • Theresa Schrage; 
  • Mirja Görlach; 
  • Christian Stephan Betz; 
  • Carsten Bokemeyer; 
  • Nicolaus Kroeger; 
  • Volkmar Mueller; 
  • Cordula Petersen; 
  • Andreas Krüll; 
  • Christiane Bleich; 
  • Holger Schulz; 

ABSTRACT

Background:

Cancer patients often suffer from the physical and psychological burden of their disease and its treatment which are frequently not sufficiently identified nor addressed in clinical routine. In the context of improving patient-centered care of oncological patients, patient-reported outcomes (PROs) represent an important addition to current routine care. So far, available PRO-measurements for cancer patients are unsuitable for routine procedures due to their length and complexity.

Objective:

Therefore, it is the aim of this study to develop and psychometrically test a short questionnaire to measure HrQoL in cancer patients for use in routine care.

Methods:

This observational study consists of two parts: [1] a qualitative study to develop a short questionnaire measuring HrQoL and [2] a quantitative study to psychometrically test this questionnaire at five oncological departments of a comprehensive cancer center. In study part 1, semi-structured interviews with 28 cancer patients as well as five focus groups with 22 clinicians and nurses will be conducted to identify clinically relevant dimensions of HrQoL. The identified dimensions will be complemented with related dimensions of empirical studies and discussed in an expert discussion. On this basis a short instrument will be developed. In study part 2, the developed questionnaire will be tested in cancer in- and out-patients of five participating oncological clinics using additional standardized questionnaires assessing HrQoL and further important PROs. The questionnaire will be presented to 770 patients twice during treatment.

Results:

x

Conclusions:

With five to six dimensions of one item each, the developed questionnaire is short enough, to not disrupt routine procedures during treatment and is profound enough, to inform clinicians about the patient’s problems and course concerning HrQoL. Clinical Trial: This study was registered at Open Science Framework (https://osf.io/y7xce/).


 Citation

Please cite as:

Schrage T, Görlach M, Betz CS, Bokemeyer C, Kroeger N, Mueller V, Petersen C, Krüll A, Bleich C, Schulz H

Development of a short instrument for measuring health related quality of life in oncological patients for the use in clinical routine – observational study protocol

JMIR Preprints. 16/01/2020:17854

DOI: 10.2196/preprints.17854

URL: https://preprints.jmir.org/preprint/17854

PMID: 32726289

PMCID: 7424483

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