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Currently submitted to: JMIR Research Protocols

Date Submitted: Nov 15, 2020
Open Peer Review Period: Nov 15, 2020 - Jan 10, 2021
(currently open for review)

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

The impact of enhanced recovery after surgery on total joint arthroplasty: A protocol for systematic review and meta-analysis

  • Siddharth Rele; 
  • Cade Shadbolt; 
  • Chris Schilling; 
  • Nicholas F Taylor; 
  • Michelle M Dowsey; 
  • Peter F M Choong



The number of total joint arthroplasty being performed is increasing worldwide. To match this increasing demand, there has been focus on hastening patients’ recovery of function. This effort has culminated in formulation of enhanced recovery for surgery (ERAS) strategies. However, with evolving ERAS programs and new recommendations, a review of current evidence is required to provide clinicians with up-to-date information about its effect on outcomes for total joint arthroplasty.


This study outlines the protocol for a systematic review and meta-analysis that aims to assess the utility of enhanced recovery after surgery programs on patient, health services and economic outcomes for primary, elective total hip and knee arthroplasty.


A systematic search will be conducted in Medline (OVID), EMCARE (OVID), Web of Science, CINAHL, National Health Service Economic Evaluations Database and the Cochrane Library. Analytical, observational and experimental designs will be included in this systematic review. Only studies including patients undergoing primary, total knee and hip arthroplasty comparing ERAS programs with conventional surgery and postoperative care will be included. Data related to patient outcomes, health service outcomes, safety and economic evaluation will be extracted.


The search terms have been finalized, and the final primary database search will be completed in November 2020. The results of this systematic review will be disseminated in a peer-reviewed journal.


This protocol will guide a systematic review assessing outcomes associated with ERAS surgery in primary, total hip and knee arthroplasty Clinical Trial: Open Science Framework. Doi: 10.17605/OSF.IO/Y4BHS


Please cite as:

Rele S, Shadbolt C, Schilling C, Taylor NF, Dowsey MM, Choong PFM

The impact of enhanced recovery after surgery on total joint arthroplasty: A protocol for systematic review and meta-analysis

JMIR Preprints. 15/11/2020:25581

DOI: 10.2196/preprints.25581


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