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The Systematic Removal of Participants Post-Randomization Can Lead to Alternate Explanations of the Results

The Systematic Removal of Participants Post-Randomization Can Lead to Alternate Explanations of the Results

The recently published study by Rooke et al [1] removed participants from the analysis who reported other treatment use during the study (n=5).

John A Cunningham

J Med Internet Res 2013;15(6):e128


Evaluating the Noninferiority of a New Photodynamic Therapy (Flexitheralight) Compared With Conventional Treatment for Actinic Keratosis: Protocol for a Phase 2 Study

Evaluating the Noninferiority of a New Photodynamic Therapy (Flexitheralight) Compared With Conventional Treatment for Actinic Keratosis: Protocol for a Phase 2 Study

The study would have been completely interrupted if at least one patient had pain rated at 5 or higher out of 10 in the N-PDT area as measured by the pain assessment scale or at least one serious adverse event related to N-PDT occurred.

Fabienne Lecomte, Anne Sophie Vignion-Dewalle, Claire Vicentini, Elise Thecua, Pascal Deleporte, Alain Duhamel, Serge Mordon, Laurent Mortier

JMIR Res Protoc 2019;8(4):e11530