Regenerative Therapy for Liver Cirrhosis Based on Intrahepatic Arterial Infusion of Autologous Subcutaneous Adipose Tissue-Derived Regenerative (Stem) Cells: Protocol for a Confirmatory Multicenter Uncontrolled Clinical Trial

Yoshio Sakai   ¹ , MD ;   Shinya Fukunishi   ² , MD ;   Masayuki Takamura   ³ , MD ;   Oto Inoue   ³ , MD ;   Shinichiro Takashima   ³ , MD ;   Soichiro Usui   ³ , MD ;   Akihiro Seki   ¹ , MD ;   Alessandro Nasti   ⁴ , PhD ;   Tuyen Thuy Bich Ho   ⁴ , MSc ;   Kazunori Kawaguchi   ¹ , MD ;   Akira Asai   ² , MD ;   Yusuke Tsuchimoto   ² , MD ;   Taro Yamashita   ⁵ , MD ;   Tatsuya Yamashita   ¹ , MD ;   Eishiro Mizukoshi   ¹ , MD ;   Masao Honda   ¹ , MD ;   Yasuhito Imai   ⁶ , PhD ;   Kenichi Yoshimura   ^{6, 7} , PhD ;   Toshinori Murayama   ⁶ , MD ;   Takashi Wada   ⁸ , MD ;   Kenichi Harada   ⁹ , MD ;   Kazuhide Higuchi   ² , MD ;   Shuichi Kaneko   ^{1, 4} , MD

¹ Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan

² Department of Gastroenterology, Osaka Medical College, Takatsuki, Japan

³ Department of Cardiovascular Medicine, Kanazawa University Hospital, Kanazawa, Japan

⁴ System Biology, Kanazawa University, Kanazawa, Japan

⁵ Department of General Medicine, Kanazawa University Hospital, Kanazawa, Japan

⁶ Innovative Clinical Research Center, Kanazawa University, Kanazawa, Japan

⁷ Center for Integrated Medical Research, Hiroshima University Hospital, Hiroshima, Japan

⁸ Department of Nephrology, Kanazawa University Hospital, Kanazawa, Japan

⁹ Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan