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Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study

Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study

The index visit was defined as the first order of a culprit medication for a given patient on a given hospitalization (encounter), with only one medication used to define each hospitalization for each patient. As such, a given individual patient could be included more than once, although each encounter (hospitalization) was only used once for each patient under a given culprit medication. The earliest date of enrollment was July 6, 2011, and the latest was April 16, 2024.

Katy E Trinkley, Steven T Simon, Michael A Rosenberg

J Med Internet Res 2025;27:e68256

Designing eHealth Interventions for Pediatric Emergency Departments: Protocol for a Usability Testing Study With Youth, Parent, and Clinician Participants

Designing eHealth Interventions for Pediatric Emergency Departments: Protocol for a Usability Testing Study With Youth, Parent, and Clinician Participants

The International Organization for Standardization describes usability as “the extent to which a system, product or service can be used by specified users to achieve specified goals with effectiveness, efficiency and satisfaction in a specified context of use” [1]. Usability testing is a method in which a product is evaluated by users as they perform tasks, and may include formative or summative testing [2].

Mari Somerville, Lori Wozney, Allyson Gallant, Janet A Curran

JMIR Res Protoc 2025;14:e64350

Early Detection of Type 1 Diabetes in First-Degree Relatives in Saudi Arabia (VISION-T1D): Protocol for a Pilot Implementation Study

Early Detection of Type 1 Diabetes in First-Degree Relatives in Saudi Arabia (VISION-T1D): Protocol for a Pilot Implementation Study

To enhance recruitment, a home testing option is provided, allowing families to conveniently perform finger-prick testing and data collection at home. After screening results are available, a research physician reviews the findings. Participants who test positive for islet autoantibodies are invited to a follow-up visit that includes personalized counseling, targeted educational interventions, and additional metabolic staging to determine their T1 D stage.

Iman S Algadi, Yazed AlRuthia, Muhammad H Mujammami, Khaled Hani Aburisheh, Metib Alotaibi, Sharifah Al Issa, Amal A Al-Saif, David Seftel, Cheng-Ting Tsai, Reem A Al Khalifah

JMIR Res Protoc 2025;14:e70575

Impact of Conversational and Animation Features of a Mental Health App Virtual Agent on Depressive Symptoms and User Experience Among College Students: Randomized Controlled Trial

Impact of Conversational and Animation Features of a Mental Health App Virtual Agent on Depressive Symptoms and User Experience Among College Students: Randomized Controlled Trial

Cognitive behavioral therapy (CBT)-based mental health apps represent a viable option to improve access to mental health resources [3]. A form of CBT, brief cognitive behavioral therapy (b CBT) has been suggested for depressive individuals as a means of maintaining the user’s attention while not requiring large amounts of the user’s time or energy.

Stephanie Six, Elizabeth Schlesener, Victoria Hill, Sabarish V Babu, Kaileigh Byrne

JMIR Ment Health 2025;12:e67381

Identifying Intersecting Factors Associated With Suicidal Thoughts and Behaviors Among Transgender and Gender Diverse Adults: Preliminary Conditional Inference Tree Analysis

Identifying Intersecting Factors Associated With Suicidal Thoughts and Behaviors Among Transgender and Gender Diverse Adults: Preliminary Conditional Inference Tree Analysis

Conditional inference trees model the nonlinear relationships between a wide range of predictors and an outcome. As a data mining approach, the conditional inference tree is a data-driven analytic strategy that identifies interacting social determinants from many candidate predictors to determine which predictors are most relevant to specific outcomes.

Amelia M Stanton, Lauren A Trichtinger, Norik Kirakosian, Simon M Li, Katherine E Kabel, Kiyan Irani, Alexandra H Bettis, Conall O’Cleirigh, Richard T Liu, Qimin Liu

J Med Internet Res 2025;27:e65452

Motivation Theories and Constructs in Experimental Studies of Online Instruction: Systematic Review and Directed Content Analysis

Motivation Theories and Constructs in Experimental Studies of Online Instruction: Systematic Review and Directed Content Analysis

For example, medical students completing an online module on a basic science topic may be confident in their ability to learn but struggle to see the value in the material beyond their next examination. Conversely, students completing a virtual examination with a standardized patient may see the value in what they are learning but not feel confident in their ability to succeed.

Adam Gavarkovs, Erin Miller, Jaimie Coleman, Tharsiga Gunasegaran, Rashmi A Kusurkar, Kulamakan Kulasegaram, Melanie Anderson, Ryan Brydges

JMIR Med Educ 2025;11:e64179

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

The aim of this study is to develop risk calculators that best predict (1) a mother’s risk of having a neonate with abnormal fetal growth (large for gestational age [LGA] or small for gestational age [SGA]); (2) a mother’s risk of having a serious adverse neonatal outcome; and (3) a mother’s risk of developing new metabolic disease after pregnancy (Figure 1).

Sarah A L Price, Digsu N Koye, Alice Lewin, Alison Nankervis, Stefan C Kane

JMIR Res Protoc 2025;14:e72542

Comparison of Deep Learning Approaches Using Chest Radiographs for Predicting Clinical Deterioration: Retrospective Observational Study

Comparison of Deep Learning Approaches Using Chest Radiographs for Predicting Clinical Deterioration: Retrospective Observational Study

Furthermore, this simplifies the prediction task to a single time point, making it more feasible to compare multiple models and augmentation strategies. Patients with a chest radiograph within 48 hours before the first elevated e CART score were included in the study. Available anterior-posterior or posterior-anterior views were included in the study cohort.

Mahmudur Rahman, Jifan Gao, Kyle A Carey, Dana P Edelson, Askar Afshar, John W Garrett, Guanhua Chen, Majid Afshar, Matthew M Churpek

JMIR AI 2025;4:e67144

Provider Perspectives on Implementing an Enhanced Digital Screening for Adolescent Depression and Suicidality: Qualitative Study

Provider Perspectives on Implementing an Enhanced Digital Screening for Adolescent Depression and Suicidality: Qualitative Study

Transcripts were coded by the first author following a template analysis approach [18] with NVivo software (version 14; Lumivero), using a prespecified codebook. The codebook was created according to a hybrid approach, using a deductive approach to generate high-level codes based on the CFIR Codebook Template [15], and an inductive approach to incorporate themes that arose from the data [19].

Morgan A Coren, Oliver Lindhiem, Abby R Angus, Emma K Toevs, Ana Radovic

JMIR Form Res 2025;9:e67624

Factors Impacting Mobile Health Adoption for Depression Care and Support by Adolescent Mothers in Nigeria: Preliminary Focus Group Study

Factors Impacting Mobile Health Adoption for Depression Care and Support by Adolescent Mothers in Nigeria: Preliminary Focus Group Study

Perinatal depression, a condition common in pregnant women, is higher among adolescent mothers than older mothers [10,11] occurring during pregnancy and up to one year after childbirth. Untreated perinatal depression is a risk for negative health outcomes for mothers and their infants [12].

Lola Kola, Tobi Fatodu, Manasseh Kola, Bisola A Olayemi, Adeyinka O Adefolarin, Simpa Dania, Manasi Kumar, Dror Ben-Zeev

JMIR Form Res 2025;9:e42406