JMIR Research Protocols

Health promoting school (HPS) interventions have the potential to improve adolescent health and well-being, but evidence regarding implementation and system-level impact in real-world school settings remains limited. “My Life – I Decide” (My Life) is a systems-oriented HPS intervention developed to strengthen positive mental and physical health, school well-being, and health-promoting school practices among 10th-grade students in Denmark.

In recent decades, millions of people globally have taken up Buddhist spiritual and secularized meditation practices, such as mindfulness, with the aim of improving their quality of life and well-being. Practitioners are recommended to continue meditating regularly for the long term; however, the effects of regular meditation practice after introductory instruction remain scientifically underexplored.

The cognitive paradigm in medical education is undergoing a transition from traditional knowledge transmission to learner-centered knowledge construction. In China, this shift is aligned with the (), which mandates high-quality, intrinsic development in nursing curricula. While constructivist learning theory (CLT)–based teaching methods (eg, problem-based learning, case-based learning, and situational simulation) have been widely explored across Chinese nursing institutions, the evidentiary base remains geographically fragmented and methodologically heterogeneous. A systematic synthesis is required to inform national, evidence-based educational reforms.

Laceback ligatures are passive stainless-steel auxiliaries tied from the first permanent molar hook to the canine bracket during the alignment phase of orthodontic fixed appliance treatment, predominantly in premolar extraction cases. Despite equivocal evidence on their effectiveness in controlling anterior tooth position, lacebacks are routinely used to stabilize flexible nickel-titanium archwires against masticatory forces. Their effects on 3 clinically important outcomes, oral hygiene, appliance complication rates, and patient-reported pain, have never been investigated in a randomized trial, representing gaps explicitly identified in a prior systematic review.

The legacy of the Soviet childcare system has contributed to persistently high rates of child institutionalization across many countries in Eastern Europe, the Caucasus and Central Asia. Although countries throughout the region have adopted deinstitutionalization and family reunification policies, most programs provide limited support to address children’s mental health needs or family functioning during the critical transition from institutional care to family and community reintegration.

Pharmacovigilance aims to protect patient safety by identifying and managing adverse events associated with pharmaceuticals. Determining the causality of these adverse events is central at both the individual case and population levels; however, it is increasingly challenging as the volume and complexity of safety data grow. Although AI and related technologies have been proposed to support causality assessment, limited research has examined how these methods are used, their information and quality requirements, or how associated risks are addressed.

Sexual violence (SV; any sexual activity where consent is not obtained or freely given) and dating violence (DV; abuse or aggression that occurs in a romantic relationship among youth) are interrelated public health concerns among youth in the United States. Despite its urgency, there is a dearth of comprehensive SV and DV prevention approaches that intervene across multiple social ecology levels (ie, at the individual, interpersonal, community, and societal levels). Therefore, the field of violence prevention has called for the development and evaluation of community-level interventions for prevention. Close to Home (C2H) is a community-driven community mobilization primary prevention program that aims to have community-level effects on reducing SV and DV, as well as improving community connection and social norms related to SV and DV, yet it has never been rigorously evaluated.

Posttraumatic stress disorder (PTSD) affects up to 25% of trauma-exposed adolescents; yet, access to evidence-based treatment remains limited in rural regions. Trauma-focused cognitive behavioral therapy (TF-CBT) is the first-line intervention, but structural barriers such as long travel distances and therapist shortages hinder implementation. Digital and blended formats may improve accessibility, but evidence for adolescents with PTSD is limited. Shame and self-criticism are common following interpersonal trauma and can reduce engagement; compassion-focused strategies target these mechanisms and aim to enhance emotional safety.

Alcohol use disorder (AUD) is a complex, chronic medical disease wherein patients have traditionally benefited from a multidisciplinary and comprehensive therapeutic approach, including a comprehensive treatment plan that addresses the psychological, behavioral, and social dimensions of the individual. Holistic health is a nontraditional system of wellness that focuses on well-being through body, mind, and spirit and aims to restore balance through combined physical, mental, and emotional care. This approach may incorporate nonpharmacological and alternative treatments alongside allopathic medicine. In recent years, there has been a growing interest in integrating holistic health strategies into addiction treatment.

High-risk subsolid pulmonary nodules, especially mixed ground-glass nodules, can represent precancerous or early-stage lung adenocarcinoma spectrum lesions. Standard management relies mainly on risk stratification, repeated thin-slice computed tomography, and invasive diagnosis or surgery when progression suggests malignancy. Safe adjunctive pharmacologic options to reduce nodule progression remain limited. Yifei Sanjie Pill (YFSJ) is an 8-herb traditional Chinese medicine formula that has been previously studied as an adjunctive treatment for non–small cell lung cancer. However, its effect on high-risk pulmonary nodules—a distinct clinical condition—has not yet been investigated.

Cerebrovascular diseases represent a major public health challenge, and stroke is among the leading causes of mortality worldwide. Among poststroke complications, pneumonia stands out because of its frequency and negative impact on clinical outcomes, including prolonged hospitalization and increased mortality. In this context, studies investigating the risk factors associated with stroke-related pneumonia differ in terms of their design, care setting, and adopted definitions.

Supporting youth and their caregivers during the transition from pediatric to adult health care is a priority across Canada. Many transition in care (TiC) innovations exist, yet these innovations often fail to be effectively implemented and/or sustained. Knowledge translation (KT) interventions, such as developing educational materials and identifying champions, are used to promote the uptake of innovations into clinical practice. However, there is limited information on what, when, and how these KT interventions are used to implement and sustain TiC innovations.