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Approach to Design and Evaluate Digital Tools to Enhance Young Adult Participation in Clinical Trials: Co-Design and Controlled Intercept Study

Approach to Design and Evaluate Digital Tools to Enhance Young Adult Participation in Clinical Trials: Co-Design and Controlled Intercept Study

A power calculation using a 2-tailed independent samples t test was conducted to ascertain the minimum surveyed sample size needed to detect statistically significant differences between control and intervention arms when assuming a minor 0.25 increase in enrollment propensity in the control arm and a full additional point (x̄=1.25) increase in enrollment propensity in the intervention arm, with appreciable variation (σ=1.5 for both arms).

Tim Mackey, Raphael E Cuomo, Qing Xu, Tiana J McMann, Zhuoran Li, Mingxiang Cai, Christine Wenzel, Joshua S Yang

J Med Internet Res 2025;27:e70852

Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study

Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study

For the consistency-based approach, we followed the best practices established in prior work [24] by sampling the LLM multiple times (number of samples=5) with high temperature (T=0.8; high randomness in generated responses) and used a majority vote weighted by the confidence of each response to determine the final deprescribing recommendation.

Vimig Socrates, Donald S Wright, Thomas Huang, Soraya Fereydooni, Christine Dien, Ling Chi, Jesse Albano, Brian Patterson, Naga Sasidhar Kanaparthy, Catherine X Wright, Andrew Loza, David Chartash, Mark Iscoe, Richard Andrew Taylor

JMIR Aging 2025;8:e69504