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Similarly, Akinci et al [33] reported that in a small cohort (n=164), prepregnancy obesity, greater gestational weight gain, and a fasting glucose level (>5.5 mmol/L) on the 75-g OGTT predicted the development of metabolic syndrome in postpartum women with moderate to high discrimination.
There are very few studies that use maternal characteristics to predict both maternal and fetal/neonatal pregnancy outcomes, even though they are inextricably linked.
JMIR Res Protoc 2025;14:e72542
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GLP-1 is released by L cells in the intestine, and research in rats suggested that leptin potently stimulated postprandial GLP-1 release via leptin receptors on intestinal L cells [31,32]. Thus, our model posits that lower leptin level is associated with blunted postprandial GLP-1 response. Supporting this prediction, individuals with higher leptin levels have demonstrated more robust GLP-1 responses to food intake [33].
JMIR Res Protoc 2025;14:e66554
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