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deal: samen werken aan duurzame zorg [Article in Dutch](https://www.rvo.nl/sites/default/files/2024-12/C-
J Med Internet Res 2025;27:e67538
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Several recent Canadian population-based studies have shown that many patients at high CVD risk continue to have low-density lipoprotein cholesterol (LDL-C) levels well above the guideline targets [2,3]. LDL-C has been extensively studied and described as a causal factor for CVD [4]. LDL-C levels above the target can result from multiple factors such as insufficient LDL-C lowering with statins, statin-related side effects, suboptimal medication adherence, and treatment inertia [5].
JMIR Cardio 2025;9:e58124
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