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Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study

Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study

For cases where the LLM and the medical students differed, 2 senior annotators (board-certified Emergency Medicine physicians) adjudicated 126 discrepancies after standardizing the codebook and verifying IRR (Cohen k: eligibility=0.795, deprescribing=0.745). Notably, the confusion matrix (Figure 4) revealed that a major source of discrepancy was the significantly higher likelihood of the LLM to recommend deprescribing (11.6%) compared to the medical students (1.91%).

Vimig Socrates, Donald S Wright, Thomas Huang, Soraya Fereydooni, Christine Dien, Ling Chi, Jesse Albano, Brian Patterson, Naga Sasidhar Kanaparthy, Catherine X Wright, Andrew Loza, David Chartash, Mark Iscoe, Richard Andrew Taylor

JMIR Aging 2025;8:e69504

Effects of Using a Smart Bassinet on the Mental Health of Military-Affiliated Pregnant Women: Protocol for a Randomized Controlled Sleep Health and Mood in Newly Expectant Military Mothers (SHINE) Trial

Effects of Using a Smart Bassinet on the Mental Health of Military-Affiliated Pregnant Women: Protocol for a Randomized Controlled Sleep Health and Mood in Newly Expectant Military Mothers (SHINE) Trial

Peripheral blood mononuclear cell (PBMC) suspensions will be prepared within 24 hours of blood collection by low-density gradient centrifugation via Hermle Z300 (K#55085010) to avoid erythrophagy-related activation of the monocytes. PBMCs will be frozen and stored at –80 °C using 10% dimethylsulfoxide, thereby allowing all samples to be analyzed in parallel. Plasma will also be stored at –80 °C.

Michele L Okun, Jennifer L Payne, Lauren M Osborne, Leilani Feliciano, Andrew Lac

JMIR Res Protoc 2025;14:e66439