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Effectiveness and Cost-Effectiveness of Survivorship Care for Survivors of Hodgkin Lymphoma (INSIGHT Study): Protocol for a Multicenter Retrospective Cohort Study With a Quasi-Experimental Design

Effectiveness and Cost-Effectiveness of Survivorship Care for Survivors of Hodgkin Lymphoma (INSIGHT Study): Protocol for a Multicenter Retrospective Cohort Study With a Quasi-Experimental Design

In brief, in an intention-to-treat analysis, taking a BETER clinic attendance rate of 65% into account (A Nijdam, unpublished data, 2016), the expected difference between the intervention and the control group is 0.40 acquired DALY over a follow-up period of 5 years (our expected median follow-up is longer). With a 2-sided significance level of .05 and 80% power to detect a difference of 0.20 SD (small effect size) and larger, we need 393 patients in each study arm.

Eline M J Lammers, Josée M Zijlstra, Valesca P Retèl, Berthe M P Aleman, Flora E van Leeuwen, Annelies Nijdam, BETER consortium

JMIR Res Protoc 2024;13:e55601