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Artificial Intelligence-Driven Biological Age Prediction Model Using Comprehensive Health Checkup Data: Development and Validation Study

Artificial Intelligence-Driven Biological Age Prediction Model Using Comprehensive Health Checkup Data: Development and Validation Study

We employed various machine learning models such as linear regression, least absolute shrinkage and selection operator (LASSO) regression, ridge regression, elastic net, random forest, support vector machine (SVM), gradient boosting, and K-nearest neighbors. These models were chosen for their ability to handle diverse relationships in data, including linear, nonlinear, and complex interactions. Hyperparameter optimization for each model was conducted using a grid search.

Chang-Uk Jeong, Jacob S Leiby, Dokyoon Kim, Eun Kyung Choe

JMIR Aging 2025;8:e64473

Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study

Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study

For cases where the LLM and the medical students differed, 2 senior annotators (board-certified Emergency Medicine physicians) adjudicated 126 discrepancies after standardizing the codebook and verifying IRR (Cohen k: eligibility=0.795, deprescribing=0.745). Notably, the confusion matrix (Figure 4) revealed that a major source of discrepancy was the significantly higher likelihood of the LLM to recommend deprescribing (11.6%) compared to the medical students (1.91%).

Vimig Socrates, Donald S Wright, Thomas Huang, Soraya Fereydooni, Christine Dien, Ling Chi, Jesse Albano, Brian Patterson, Naga Sasidhar Kanaparthy, Catherine X Wright, Andrew Loza, David Chartash, Mark Iscoe, Richard Andrew Taylor

JMIR Aging 2025;8:e69504