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How to Design Electronic Case Report Form (eCRF) Questions to Maximize Semantic Interoperability in Clinical Research

How to Design Electronic Case Report Form (eCRF) Questions to Maximize Semantic Interoperability in Clinical Research

Common recommendations for e CRF design include suggestions to reduce data entry errors and ambiguity in the interpretation of variables such as maximizing the use of coded questions and answer lists and minimizing the use of free text answers; using built-in consistency checks for admissible ranges and plausible date checks; facilitating data entry using branching logic strategies; specifying units of measurement (particularly for laboratory parameters, but also for vital signs, etc); adopting standard data

Eugenia Rinaldi, Caroline Stellmach, Sylvia Thun

Interact J Med Res 2025;14:e51598

Digital Interventions for Older People Experiencing Homelessness: Systematic Scoping Review

Digital Interventions for Older People Experiencing Homelessness: Systematic Scoping Review

Policy for digital inclusion of older people experiencing homelessness should prioritize free and accessible technology in public settings (eg, shelters, community centers, libraries, and harm reduction centers) and free access to mobile devices. Action is needed across government, public, private, and third-sector organizations to ensure capitalization on the potential for digital interventions to address health and well-being while minimizing the risk of exacerbating existing health inequalities.

Emily Adams, Eddie Donaghy, Caroline Sanders, Maria Klara Wolters, Lauren Ng, Christa St-Jean, Ryan Galan, Stewart William Mercer

J Med Internet Res 2025;27:e63898

Designing Health Recommender Systems to Promote Health Equity: A Socioecological Perspective

Designing Health Recommender Systems to Promote Health Equity: A Socioecological Perspective

For individuals living in areas where outdoor activities may be unsafe or impossible because of weather conditions, physical activity HRS could offer alternative options, such as indoor exercises, community-centered physical activities, or free web-based classes. Furthermore, HRS can also empower users through prioritizing user decisions over system performance, which is related to digital self-efficacy, and facilitates trust in HRS.

Caroline A Figueroa, Helma Torkamaan, Ananya Bhattacharjee, Hanna Hauptmann, Kathleen W Guan, Gayane Sedrakyan

J Med Internet Res 2025;27:e60138

Integrating Videoconferencing Therapist Guidance Into Stepped Care Internet-Delivered Cognitive Behavioral Therapy for Child and Adolescent Anxiety: Noninferiority Randomized Controlled Trial

Integrating Videoconferencing Therapist Guidance Into Stepped Care Internet-Delivered Cognitive Behavioral Therapy for Child and Adolescent Anxiety: Noninferiority Randomized Controlled Trial

The proportion of participants free of their primary and any anxiety diagnosis increased over time for both conditions. For the per-protocol analysis, there were no significant differences between the conditions in the proportion of participants free of their primary or any anxiety diagnosis at 12 weeks, although by 9 months, a significantly higher proportion of participants in the ICBT-TG[VC] condition were free of their primary and any anxiety diagnosis.

Sonja March, Susan H Spence, Larry Myers, Martelle Ford, Genevieve Smith, Caroline L Donovan

JMIR Ment Health 2025;12:e57405