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Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study

Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study

For cases where the LLM and the medical students differed, 2 senior annotators (board-certified Emergency Medicine physicians) adjudicated 126 discrepancies after standardizing the codebook and verifying IRR (Cohen k: eligibility=0.795, deprescribing=0.745). Notably, the confusion matrix (Figure 4) revealed that a major source of discrepancy was the significantly higher likelihood of the LLM to recommend deprescribing (11.6%) compared to the medical students (1.91%).

Vimig Socrates, Donald S Wright, Thomas Huang, Soraya Fereydooni, Christine Dien, Ling Chi, Jesse Albano, Brian Patterson, Naga Sasidhar Kanaparthy, Catherine X Wright, Andrew Loza, David Chartash, Mark Iscoe, Richard Andrew Taylor

JMIR Aging 2025;8:e69504

Digital Health Intervention on Awareness of Vaccination Against Influenza Among Adults With Diabetes: Pragmatic Randomized Follow-Up Study

Digital Health Intervention on Awareness of Vaccination Against Influenza Among Adults With Diabetes: Pragmatic Randomized Follow-Up Study

Cramer V test was applied for measuring the effect size of correlation between categorical fields and Cohen d for measuring the effect size of the differences between 2 group means [32]. A logistic regression model was used to estimate the probability of independent correlations between survey answers and the study groups. The P values, odds ratios (ORs), and 95% CIs associated with each of the β parameter estimates were reported.

Yifat Fundoiano-Hershcovitz, Felix Lee, Catherine Stanger, Inbar Breuer Asher, David L Horwitz, Omar Manejwala, Jan Liska, David Kerr

J Med Internet Res 2025;27:e68936

Assessing the Noninferiority of a Rhythm and Language Training Serious Game Combined With Speech Therapy Versus Speech Therapy Care for Children With Dyslexia: Protocol for an Investigator-Blinded Randomized Controlled Trial

Assessing the Noninferiority of a Rhythm and Language Training Serious Game Combined With Speech Therapy Versus Speech Therapy Care for Children With Dyslexia: Protocol for an Investigator-Blinded Randomized Controlled Trial

The maximum acceptable inferiority for experimental versus control on the primary outcome is therefore expected to be a standardized difference (Cohen d=0.39), which corresponds to a label between small or medium, depending on the guidelines (R effect size package) [44]. Considering a one-sided significance level of 2.5% and a power of 90%, it is necessary to include 137 participants per group (G*Power 3.1).

Charline Grossard, Mélanie Descamps, Sara Cadoni, Hugues Pellerin, François Vonthron, Jean Xavier, Bruno Falissard, David Cohen

JMIR Res Protoc 2025;14:e71326