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Safety and Efficacy of Modular Digital Psychotherapy for Social Anxiety: Randomized Controlled Trial

Safety and Efficacy of Modular Digital Psychotherapy for Social Anxiety: Randomized Controlled Trial

Social anxiety disorder (SAD) is a prevalent and debilitating mental health challenge that affects a substantial portion of the global population at some point in their lives [1,2]. Characterized by a persistent fear of social situations, SAD can severely limit a person’s ability to engage in everyday activities, from forming personal relationships to navigating work and educational settings.

Mona M Garvert, Jessica McFadyen, Stuart Linke, Tayla McCloud, Sofie S Meyer, Sandra Sobanska, Paul B Sharp, Alex Long, Quentin J M Huys, Mandana Ahmadi

J Med Internet Res 2025;27:e64138

Factors Impacting Mobile Health Adoption for Depression Care and Support by Adolescent Mothers in Nigeria: Preliminary Focus Group Study

Factors Impacting Mobile Health Adoption for Depression Care and Support by Adolescent Mothers in Nigeria: Preliminary Focus Group Study

Perinatal depression, a condition common in pregnant women, is higher among adolescent mothers than older mothers [10,11] occurring during pregnancy and up to one year after childbirth. Untreated perinatal depression is a risk for negative health outcomes for mothers and their infants [12].

Lola Kola, Tobi Fatodu, Manasseh Kola, Bisola A Olayemi, Adeyinka O Adefolarin, Simpa Dania, Manasi Kumar, Dror Ben-Zeev

JMIR Form Res 2025;9:e42406

Co-Designing a Web-Based and Tablet App to Evaluate Clinical Outcomes of Early Psychosis Service Users in a Learning Health Care Network: User-Centered Design Workshop and Pilot Study

Co-Designing a Web-Based and Tablet App to Evaluate Clinical Outcomes of Early Psychosis Service Users in a Learning Health Care Network: User-Centered Design Workshop and Pilot Study

In this text, we use the term service user to refer to the individual with a psychosis diagnosis who is receiving mental health care from an early psychosis program. We use the term support person to refer to any person that the service user has chosen to involve in their care. This is typically the individual’s parent but might be another family member, a friend, a partner, or some other close relative.

Kathleen E Burch, Valerie L Tryon, Katherine M Pierce, Laura M Tully, Sabrina Ereshefsky, Mark Savill, Leigh Smith, Adam B Wilcox, Christopher Komei Hakusui, Viviana E Padilla, Amanda P McNamara, Merissa Kado-Walton, Andrew J Padovani, Chelyah Miller, Madison J Miles, Nitasha Sharma, Khanh Linh H Nguyen, Yi Zhang, Tara A Niendam

JMIR Hum Factors 2025;12:e65889

Identifying Unmet Needs of Informal Dementia Caregivers in Clinical Practice: User-Centered Development of a Digital Assessment Tool

Identifying Unmet Needs of Informal Dementia Caregivers in Clinical Practice: User-Centered Development of a Digital Assessment Tool

In phase 2, the chosen assessment version covering most unmet needs was tested in a memory clinic. A tablet computer was deemed most appropriate to serve as digital device due to its size, weight, flexibility, and ease of handling. Based on a previous study on the use of a tablet-based digital expert system [26,28,30], we had taken several decisions on the hardware basis of our system before the participatory part of our study started.

Olga A Biernetzky, Jochen René Thyrian, Melanie Boekholt, Matthias Berndt, Wolfgang Hoffmann, Stefan J Teipel, Ingo Kilimann

JMIR Aging 2025;8:e59942

Anticipated Acceptability of Blended Learning Among Lay Health Care Workers in Malawi: Qualitative Analysis Guided by the Technology Acceptance Model

Anticipated Acceptability of Blended Learning Among Lay Health Care Workers in Malawi: Qualitative Analysis Guided by the Technology Acceptance Model

Perceived usefulness refers to the belief that a certain technology would increase an individual’s job performance. Perceived ease of use is a belief that the use of the new technology would be effortless [27]. TAM proposes that a populations’ perceptions of usefulness and ease of use of a technology impact the population’s intention to use the technology, which in turn influences the population’s actual usage of the technology.

Tiwonge E Mbeya-Munkhondya, Caroline J Meek, Mtisunge Mphande, Tapiwa A Tembo, Mike J Chitani, Milenka Jean-Baptiste, Caroline Kumbuyo, Dhrutika Vansia, Katherine R Simon, Sarah E Rutstein, Victor Mwapasa, Vivian Go, Maria H Kim, Nora E Rosenberg

JMIR Form Res 2025;9:e62741

A Culturally Tailored Artificial Intelligence Chatbot (K-Bot) to Promote Human Papillomavirus Vaccination Among Korean Americans: Development and Usability Study

A Culturally Tailored Artificial Intelligence Chatbot (K-Bot) to Promote Human Papillomavirus Vaccination Among Korean Americans: Development and Usability Study

Korean Americans are at a relatively high risk for HPV-related cancers, yet they exhibit significant disparities in HPV vaccination rates [6,7]. Notably, Korean American women demonstrate a particularly low intention to receive the HPV vaccine, with only 34.6% expressing a willingness to get the vaccine in prior studies [8].

Minjin Kim, Ellie Kim, Hyeongsuk Lee, Meihua Piao, Brittany Rosen, Jeroan J Allison, Adrian H Zai, Hoa L Nguyen, Dong-Soo Shin, Jessica A Kahn

Asian Pac Isl Nurs J 2025;9:e71865

Evaluation of Large Language Models in Tailoring Educational Content for Cancer Survivors and Their Caregivers: Quality Analysis

Evaluation of Large Language Models in Tailoring Educational Content for Cancer Survivors and Their Caregivers: Quality Analysis

The FKG level is a readability test designed to indicate how difficult a text is to understand. It calculates the grade level required for someone to comprehend the text. The FKG is based on word length and sentence length, providing a numerical score that corresponds to US grade levels [42]. The National Institutes of Health (NIH) and the American Medical Association (AMA) suggest that patient education materials should be written at a reading level no higher than the sixth grade [43].

Darren Liu, Xiao Hu, Canhua Xiao, Jinbing Bai, Zahra A Barandouzi, Stephanie Lee, Caitlin Webster, La-Urshalar Brock, Lindsay Lee, Delgersuren Bold, Yufen Lin

JMIR Cancer 2025;11:e67914

Effectiveness of Virtual Reality–Complemented Pulmonary Rehabilitation on Lung Function, Exercise Capacity, Dyspnea, and Health Status in Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis

Effectiveness of Virtual Reality–Complemented Pulmonary Rehabilitation on Lung Function, Exercise Capacity, Dyspnea, and Health Status in Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis

Because of the high heterogeneity, a sensitivity analysis was conducted by removing the study by Rutkowski et al [41]. This study was excluded due to differences in disease severity, with the intervention and control groups having a significantly better baseline lung function compared with the other studies, potentially leading to a different treatment response. After excluding this study, heterogeneity reduced to 0%, and a fixed-effect model was applied.

Yuyin Chen, Yuanyuan Zhang, Xiuhong Long, Huiqiong Tu, Jibing Chen

J Med Internet Res 2025;27:e64742

Racial Disparities in Parkinson Disease Clinical Phenotype, Management, and Genetics: Protocol for a Prospective Observational Study

Racial Disparities in Parkinson Disease Clinical Phenotype, Management, and Genetics: Protocol for a Prospective Observational Study

The long-term goal of this application is to address the critical gap in knowledge of PD in this underserved population to improve diagnosis, optimize treatment, and plan for clinical trials. The central hypothesis is: PD is phenotypically and genetically different in Black versus White populations, and Black patients receive different and suboptimal clinical management.

Deborah A Hall, Josh M Shulman, Andrew Singleton, Sara Bandres Ciga, Michelle Hyczy S Tosin, Bichun Ouyang, Lisa Shulman

JMIR Res Protoc 2025;14:e60587

Health Care Professionals' Engagement With Digital Mental Health Interventions in the United Kingdom and China: Mixed Methods Study on Engagement Factors and Design Implications

Health Care Professionals' Engagement With Digital Mental Health Interventions in the United Kingdom and China: Mixed Methods Study on Engagement Factors and Design Implications

Many recent reviews have shown that low engagement is a ubiquitous problem among DMHIs [17-19]. Plus, user engagement is considerably lower in naturalistic settings than in empirical studies [19-21]. To illustrate this, a review of 59 off-the-shelf mental health apps reported a median uptake rate of 4.0% and a 15-day retention rate of only 3.9% [22].

Zheyuan Zhang, Sijin Sun, Laura Moradbakhti, Andrew Hall, Celine Mougenot, Juan Chen, Rafael A Calvo

JMIR Ment Health 2025;12:e67190