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A Risk Prediction Model (CMC-AKIX) for Postoperative Acute Kidney Injury Using Machine Learning: Algorithm Development and Validation

A Risk Prediction Model (CMC-AKIX) for Postoperative Acute Kidney Injury Using Machine Learning: Algorithm Development and Validation

Acute kidney injury (AKI) represents a critical challenge in postoperative care, significantly affecting patient outcomes and health care systems. It is a common complication that affects up to 5% to 7.5% of all hospitalized patients, with a markedly higher prevalence of 20% in intensive care units [1]. Among all AKI in hospitalized patients, 40% occur in postoperative patients [1].

Ji Won Min, Jae-Hong Min, Se-Hyun Chang, Byung Ha Chung, Eun Sil Koh, Young Soo Kim, Hyung Wook Kim, Tae Hyun Ban, Seok Joon Shin, In Young Choi, Hye Eun Yoon

J Med Internet Res 2025;27:e62853

Online Information About Side Effects and Safety Concerns of Semaglutide: Mixed Methods Study of YouTube Videos

Online Information About Side Effects and Safety Concerns of Semaglutide: Mixed Methods Study of YouTube Videos

In particular, many people have watched You Tube videos on weight loss. It was found that the 98 most viewed weight loss videos on You Tube were viewed more than 365 million times in total [9]. In recent years, the injectable antidiabetic drug with weight loss property, branded Ozempic, has gained significant attention on platforms such as Tik Tok (Byte Dance) and You Tube. Between 2018 and 2023, online searches for Ozempic surged in the United States [10].

Andy Wai Kan Yeung, Fabian Peter Hammerle, Sybille Behrens, Maima Matin, Michel-Edwar Mickael, Olena Litvinova, Emil D Parvanov, Maria Kletecka-Pulker, Atanas G Atanasov

JMIR Infodemiology 2025;5:e59767

Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

In a PR task for food reward, breakpoint was increased by knockdown of leptin receptor expression in the midbrain, including the VTA, but not the hypothalamus [43] and directly in the VTA, but not the substantia nigra [44]. Leptin activation of pro-opiomelanocortin/CART neurons decreases food intake in ad-lib meals across species, including humans [45]. In contrast, NPY/Ag RP potently stimulate increased food intake [37].

Pamela K Keel, Lindsay P Bodell, Sarrah I Ali, Austin Starkey, Jenna Trotta, J Woody Luxama, Chloé Halfhide, Naomi G Hill, Jonathan Appelbaum, Diana L Williams

JMIR Res Protoc 2025;14:e66554

Examining the Client Experience of Digital Tools in Blended Care Therapy: Qualitative Interview Study

Examining the Client Experience of Digital Tools in Blended Care Therapy: Qualitative Interview Study

In LCT, clients participate in synchronous telehealth therapy sessions and in asynchronous guided practice sessions. The average length of an LCT episode is 6 synchronous therapy sessions over 8 weeks [14]. Consistent with best practices in mental health care, Lyra Care therapists are trained in and receive ongoing supervision and consultation on evidence-based mental health care [15,16].

Emily G Lattie, Miranda Beltzer, Alethea Varra, Connie E Chen, Anita Lungu

JMIR Form Res 2025;9:e68249

Analysis of Metabolic and Quality-of-Life Factors in Patients With Cancer for a New Approach to Classifying Walking Habits: Secondary Analysis of a Randomized Controlled Trial

Analysis of Metabolic and Quality-of-Life Factors in Patients With Cancer for a New Approach to Classifying Walking Habits: Secondary Analysis of a Randomized Controlled Trial

At the same time, commercial smartphone apps have many limitations in research, especially in collecting physical activity data over a sufficient period [16]. Consequently, the practical application of the research results to patients with cancer in the real world is limited, although e Health tools can provide a potent resource to facilitate personalized and accessible care in daily life [11,12].

Yae Won Tak, Junetae Kim, Haekwon Chung, Sae Byul Lee, In Ja Park, Sei Won Lee, Min-Woo Jo, Jong Won Lee, Seunghee Baek, Yura Lee

J Med Internet Res 2025;27:e52694

Pharmacist-Initiated Team-Based Intervention for Optimizing Guideline-Directed Lipid Therapy of Hospitalized Patients With Acute Coronary Syndrome: Pilot Study Using a Stepped-Wedge Cluster Design

Pharmacist-Initiated Team-Based Intervention for Optimizing Guideline-Directed Lipid Therapy of Hospitalized Patients With Acute Coronary Syndrome: Pilot Study Using a Stepped-Wedge Cluster Design

Secondary outcomes were (1) proportion of patients in the intervention group with the specific templated pharmacist intervention note in the EHR, (2) frequency of LDL measurements in the hospital, (3) proportion of patients with information related to lipid follow-up in their discharge summary, and (4) proportion of patients that received LDL monitoring at outpatient follow-up 4 to 12 weeks post discharge.

Gayle L Flo, Mateo Alzate Aguirre, Benjamin R Gochanour, Kristin J Hynes, Christopher G Scott, Angela L Fink, Adelaide M Arruda-Olson

JMIR Cardio 2025;9:e58837

Acceptability of a Web-Based Health App (PortfolioDiet.app) to Translate a Nutrition Therapy for Cardiovascular Disease in High-Risk Adults: Mixed Methods Randomized Ancillary Pilot Study

Acceptability of a Web-Based Health App (PortfolioDiet.app) to Translate a Nutrition Therapy for Cardiovascular Disease in High-Risk Adults: Mixed Methods Randomized Ancillary Pilot Study

The clinical Portfolio Diet Score (c-PDS) has previously been validated in a similar population of adults with hyperlipidemia [32]. By following the Portfolio Diet, users can earn up to 5 points from each category of Portfolio Diet foods for a maximum c-PDS of 25 points per day in the app. It has previously been shown that an increase in c-PDS by 12 points predicts about a 0.53 mmol/L (13%) reduction in LDL-C in patients with hyperlipidemia over 6 months [32].

Meaghan E Kavanagh, Laura Chiavaroli, Selina M Quibrantar, Gabrielle Viscardi, Kimberly Ramboanga, Natalie Amlin, Melanie Paquette, Sandhya Sahye-Pudaruth, Darshna Patel, Shannan M Grant, Andrea J Glenn, Sabrina Ayoub-Charette, Andreea Zurbau, Robert G Josse, Vasanti S Malik, Cyril W C Kendall, David J A Jenkins, John L Sievenpiper

JMIR Cardio 2025;9:e58124

Developing a Multisensor-Based Machine Learning Technology (Aidar Decompensation Index) for Real-Time Automated Detection of Post–COVID-19 Condition: Protocol for an Observational Study

Developing a Multisensor-Based Machine Learning Technology (Aidar Decompensation Index) for Real-Time Automated Detection of Post–COVID-19 Condition: Protocol for an Observational Study

Severe complications of postacute COVID-19 infection like thrombosis, respiratory failure, and cardiac and vascular damage increase the likelihood of future morbidity and mortality in recovered patients. In one study of individuals who had been hospitalized with COVID-19, nearly a third (14,060/47,780, 29.4%) of individuals who were discharged from the hospital after acute COVID-19 were readmitted, and more than 1 in 10 (5875/47,780, 12.3%) died over a follow-up period of 140 days after discharge [1].

Jenny Mathew, Jaclyn A Pagliaro, Sathyanarayanan Elumalai, Lauren K Wash, Ka Ly, Alison J Leibowitz, Varsha G Vimalananda

JMIR Res Protoc 2025;14:e54993

Feasibility, Acceptability, and Potential Effects of a Digital Oral Anticancer Agent Intervention: Protocol for a Pilot Randomized Controlled Trial

Feasibility, Acceptability, and Potential Effects of a Digital Oral Anticancer Agent Intervention: Protocol for a Pilot Randomized Controlled Trial

As OAAs are taken at home rather than in cancer centers or hospitals, medication management resides with patients- requiring them to be active in their care [7]. For OAAs to be as effective as possible and demonstrate outcomes equivalent to those seen in clinical trials, patients must follow best practices for their treatment, resulting in added responsibilities for medication management [8].

Saima Ahmed, Christine Maheu, Walter Gotlieb, Gerald Batist, Carmen G Loiselle

JMIR Res Protoc 2025;14:e55475