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Data Interoperability in COVID-19 Vaccine Trials: Methodological Approach in the VACCELERATE Project

Data Interoperability in COVID-19 Vaccine Trials: Methodological Approach in the VACCELERATE Project

Neutralizing antibody titers to live wild-type SARS-Co V-2 plaque reduction neutralization test (PRNT50) assay, and pseudovirion-expressing S protein from different variants as measured by NT50 or flow cytometry–based microneutralization assay; expressed as IU/ml Th1b and Th2 immune responses Flow cytometry after SARS-Co V-2 S protein peptide stimulation of peripheral blood mononuclear cells and intracellular staining, including CD4+c/CD8+ interferon-gamma, interleukin-2, tumor necrosis factor-alpha, interleukin

Salma Malik, Zoi Pana Dorothea, Christos D Argyropoulos, Sophia Themistocleous, Alan J Macken, Olena Valdenmaiier, Frank Scheckenbach, Elena Bardach, Andrea Pfeiffer, Katherine Loens, Jordi Cano Ochando, Oliver A Cornely, Jacques Demotes-Mainard, Sergio Contrino, Gerd Felder

JMIR Med Inform 2025;13:e65590