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Online Information About Side Effects and Safety Concerns of Semaglutide: Mixed Methods Study of YouTube Videos

Online Information About Side Effects and Safety Concerns of Semaglutide: Mixed Methods Study of YouTube Videos

A recent case series reported that compounded semaglutide might be dispensed in vials instead of prefilled manufactured injection pens such as those by Ozempic and Wegovy [42]. Vials that contain large volumes of semaglutide and vials dispensed together with subpar syringes might allow for overdose much more easily during self-administration [42].

Andy Wai Kan Yeung, Fabian Peter Hammerle, Sybille Behrens, Maima Matin, Michel-Edwar Mickael, Olena Litvinova, Emil D Parvanov, Maria Kletecka-Pulker, Atanas G Atanasov

JMIR Infodemiology 2025;5:e59767

Clinical Benefits and Risks of Antiamyloid Antibodies in Sporadic Alzheimer Disease: Systematic Review and Network Meta-Analysis With a Web Application

Clinical Benefits and Risks of Antiamyloid Antibodies in Sporadic Alzheimer Disease: Systematic Review and Network Meta-Analysis With a Web Application

This has been implemented as it can be important for calculating the benefits and risks for patient populations with different expectations of baseline risks, based on prior history and clinical expertise in each particular case. The web application Alz Meta.app 2.0 [44] has been mainly built in RStudio 2024.09 (R 4.4.1) by modifying and expanding the previous instance of the application, relying on key packages such as shiny, tidyverse, dmetar, metafor, ggplot2, netmeta, rjags, and gemtc.

Danko Jeremic, Juan D Navarro-Lopez, Lydia Jimenez-Diaz

J Med Internet Res 2025;27:e68454

Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial

Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial

The clinical effectiveness (in this case, meaning the degree of beneficial effect [70]) component of the trial will be completed using a pragmatic, cluster randomized design (randomized at the level of the clinic) with intervention clinics receiving the 5-Cog paradigm and control clinics receiving enhanced usual care (cognitive concern information and cognitive impairment detection education provided but no detection approach or clinical decision support tool implemented).

Rachel Beth Rosansky Chalmer, Emmeline Ayers, Erica F Weiss, Nicole R Fowler, Andrew Telzak, Diana Summanwar, Jessica Zwerling, Cuiling Wang, Huiping Xu, Richard J Holden, Kevin Fiori, Dustin D French, Celeste Nsubayi, Asif Ansari, Paul Dexter, Anna Higbie, Pratibha Yadav, James M Walker, Harrshavasan Congivaram, Dristi Adhikari, Mairim Melecio-Vazquez, Malaz Boustani, Joe Verghese

JMIR Res Protoc 2025;14:e60471

Perspectives of Adolescents and Young Adults With Inflammatory Bowel Disease on a Biopsychosocial Transition Intervention: Qualitative Interview Study

Perspectives of Adolescents and Young Adults With Inflammatory Bowel Disease on a Biopsychosocial Transition Intervention: Qualitative Interview Study

In one case, this led to a participant receiving a diagnosis for longstanding anxiety symptoms and subsequently accessing mental health supports: Before I got diagnosed with generalized anxiety, I talked to my transition navigator about how I was feeling and how I didn't really know how to cope. She helped me make the decision to go see a doctor about it to see if [I] could get prescribed medication or get some sort of diagnosis.

Brooke Allemang, Ashleigh Miatello, Mira Browne, Melanie Barwick, Pranshu Maini, Joshua Eszczuk, Chetan Pandit, Tandeep Sadhra, Laura Forhan, Natasha Bollegala, Nancy Fu, Kate Lee, Emily Dekker, Irina Nistor, Sara Ahola Kohut, Laurie Keefer, Anne Marie Griffiths, Thomas D Walters, Samantha Micsinszki, David R Mack, Sally Lawrence, Karen I Kroeker, Jacqueline de Guzman, Aalia Tausif, Claudia Tersigni, Samantha J Anthony, Eric I Benchimol

JMIR Pediatr Parent 2025;8:e64618

Accelerometry-Assessed Physical Activity and Circadian Rhythm to Detect Clinical Disability Status in Multiple Sclerosis: Cross-Sectional Study

Accelerometry-Assessed Physical Activity and Circadian Rhythm to Detect Clinical Disability Status in Multiple Sclerosis: Cross-Sectional Study

Nevertheless, in our case, the fifth f PC explained a significant proportion of the total variability (4%) and was also included. Figure S3 in Multimedia Appendix 1 shows that the additional f PCs beyond the 5th did not provide meaningful explanations of variability. The Joint and Individual Variation Explained (JIVE) is an integrative dimension reduction technique that can be applied to multiple features grouped within several domains [28].

Nicole Bou Rjeily, Muraleetharan Sanjayan, Pratim Guha Niyogi, Blake E Dewey, Alexandra Zambriczki Lee, Christy Hulett, Gabriella Dagher, Chen Hu, Rafal D Mazur, Elena M Kenney, Erin Brennan, Anna DuVal, Peter A Calabresi, Vadim Zipunnikov, Kathryn C Fitzgerald, Ellen M Mowry

JMIR Mhealth Uhealth 2025;13:e57599

Limitations of Binary Classification for Long-Horizon Diagnosis Prediction and Advantages of a Discrete-Time Time-to-Event Approach: Empirical Analysis

Limitations of Binary Classification for Long-Horizon Diagnosis Prediction and Advantages of a Discrete-Time Time-to-Event Approach: Empirical Analysis

Each observation was represented by the triplet {X,T,S}, where X⊆Rd is a d-dimensional feature vector, T∈(0,Emax] is an observed event or censoring time over a finite time horizon, and S∈{0,1} indicates whether T is a right-censoring time (S=0) or an event time (S=1). The observed time T is the minimum of the event time E and the right-censoring time C, that is, T=min(E, C).

De Rong Loh, Elliot D Hill, Nan Liu, Geraldine Dawson, Matthew M Engelhard

JMIR AI 2025;4:e62985