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A recent case series reported that compounded semaglutide might be dispensed in vials instead of prefilled manufactured injection pens such as those by Ozempic and Wegovy [42]. Vials that contain large volumes of semaglutide and vials dispensed together with subpar syringes might allow for overdose much more easily during self-administration [42].
JMIR Infodemiology 2025;5:e59767
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This has been implemented as it can be important for calculating the benefits and risks for patient populations with different expectations of baseline risks, based on prior history and clinical expertise in each particular case.
The web application Alz Meta.app 2.0 [44] has been mainly built in RStudio 2024.09 (R 4.4.1) by modifying and expanding the previous instance of the application, relying on key packages such as shiny, tidyverse, dmetar, metafor, ggplot2, netmeta, rjags, and gemtc.
J Med Internet Res 2025;27:e68454
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The clinical effectiveness (in this case, meaning the degree of beneficial effect [70]) component of the trial will be completed using a pragmatic, cluster randomized design (randomized at the level of the clinic) with intervention clinics receiving the 5-Cog paradigm and control clinics receiving enhanced usual care (cognitive concern information and cognitive impairment detection education provided but no detection approach or clinical decision support tool implemented).
JMIR Res Protoc 2025;14:e60471
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In one case, this led to a participant receiving a diagnosis for longstanding anxiety symptoms and subsequently accessing mental health supports:
Before I got diagnosed with generalized anxiety, I talked to my transition navigator about how I was feeling and how I didn't really know how to cope. She helped me make the decision to go see a doctor about it to see if [I] could get prescribed medication or get some sort of diagnosis.
JMIR Pediatr Parent 2025;8:e64618
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Nevertheless, in our case, the fifth f PC explained a significant proportion of the total variability (4%) and was also included. Figure S3 in Multimedia Appendix 1 shows that the additional f PCs beyond the 5th did not provide meaningful explanations of variability.
The Joint and Individual Variation Explained (JIVE) is an integrative dimension reduction technique that can be applied to multiple features grouped within several domains [28].
JMIR Mhealth Uhealth 2025;13:e57599
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Each observation was represented by the triplet {X,T,S}, where X⊆Rd is a d-dimensional feature vector, T∈(0,Emax] is an observed event or censoring time over a finite time horizon, and S∈{0,1} indicates whether T is a right-censoring time (S=0) or an event time (S=1). The observed time T is the minimum of the event time E and the right-censoring time C, that is, T=min(E, C).
JMIR AI 2025;4:e62985
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