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Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Similarly, Akinci et al [33] reported that in a small cohort (n=164), prepregnancy obesity, greater gestational weight gain, and a fasting glucose level (>5.5 mmol/L) on the 75-g OGTT predicted the development of metabolic syndrome in postpartum women with moderate to high discrimination. There are very few studies that use maternal characteristics to predict both maternal and fetal/neonatal pregnancy outcomes, even though they are inextricably linked.

Sarah A L Price, Digsu N Koye, Alice Lewin, Alison Nankervis, Stefan C Kane

JMIR Res Protoc 2025;14:e72542

Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

GLP-1 is released by L cells in the intestine, and research in rats suggested that leptin potently stimulated postprandial GLP-1 release via leptin receptors on intestinal L cells [31,32]. Thus, our model posits that lower leptin level is associated with blunted postprandial GLP-1 response. Supporting this prediction, individuals with higher leptin levels have demonstrated more robust GLP-1 responses to food intake [33].

Pamela K Keel, Lindsay P Bodell, Sarrah I Ali, Austin Starkey, Jenna Trotta, J Woody Luxama, Chloé Halfhide, Naomi G Hill, Jonathan Appelbaum, Diana L Williams

JMIR Res Protoc 2025;14:e66554