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A Dynamic Adaptive Ensemble Learning Framework for Noninvasive Mild Cognitive Impairment Detection: Development and Validation Study

Neurodegenerative conditions such as Alzheimer disease (AD) and related dementias precipitate accelerated cognitive deterioration, markedly impacting patients’ daily lives and social engagement [1]. Current estimates suggest that approximately 50 million individuals worldwide suffer from dementia, with this number expected to soar to 152 million by 2050 [2]. Generally, patients diagnosed with mild cognitive impairment (MCI) are at a much higher risk of developing dementia [3].

Aoyu Li, Jingwen Li, Yishan Hu, Yan Geng, Yan Qiang, Juanjuan Zhao

JMIR Med Inform 2025;13:e60250

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The PDC30 Chatbot—Development of a Psychoeducational Resource on Dementia Caregiving Among Family Caregivers: Mixed Methods Acceptability Study

Reference 34: Benefit-finding intervention for Alzheimer caregivers: conceptual framework, implementation Reference 35: A benefit-finding intervention for family caregivers of persons with Alzheimer disease: Reference 37: Long-term outcomes of the benefit-finding group intervention for Alzheimer family caregivers Reference 38: Benefit-finding intervention delivered individually to Alzheimer family caregivers: longer-termalzheimer

Sheung-Tak Cheng, Peter H F Ng

JMIR Aging 2025;8:e63715

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The Needs and Experiences of People With Early-Stage Dementia Using an Application for Cognitive and Physical Activation in Germany: Qualitative Study

Reference 2: World Alzheimer Report 2018: the state of the art of dementia research(https://www.alzint.orgalzheimer

Melina Klein, Alexa von Bosse, Christophe Kunze

JMIR Aging 2024;7:e62689

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A Multivariable Prediction Model for Mild Cognitive Impairment and Dementia: Algorithm Development and Validation

Early detection of MCI is important for optimizing patient care, potentially enabling the timely use of disease-modifying therapies to prevent Alzheimer disease (AD) and related dementia [4]. As the life expectancy of patients with AD is approximately 8-10 years after symptom onset, preventing disease progression at an early stage is crucial [3].

Sarah Soyeon Oh, Bada Kang, Dahye Hong, Jennifer Ivy Kim, Hyewon Jeong, Jinyeop Song, Minkyu Jeon

JMIR Med Inform 2024;12:e59396

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Remote Passive Sensing of Older Adults’ Activities and Function: User-Centered Design Considerations for Behavioral Interventions Conducted in the Home Setting

Subtle decline in everyday function occurs as part of the normal aging process and as a symptom of pathologies commonly found among older adults, such as Alzheimer disease and related disorders. Likewise, stress from caregiving for older adults with chronic health conditions impacts everyday routines and behaviors such as sleep and physical activity.

Lyndsey M Miller, Jeffrey Kaye, Allison Lindauer, Wan-Tai M Au-Yeung, Nathaniel K Rodrigues, Sara J Czaja

J Med Internet Res 2024;26:e54709

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Investigating Acoustic and Psycholinguistic Predictors of Cognitive Impairment in Older Adults: Modeling Study

Prior studies have reported speech and language declines across disease progression from early MCI to moderate-stage Alzheimer disease [6-8]. Mueller et al [8] found that subtle declines in speech fluency and semantic content are apparent even prior to the onset of clinically diagnosed MCI. Therefore, developing techniques to identify early changes in language functioning may enhance the detection of subtle cognitive decline associated with pathological cognitive aging.

Varsha D Badal, Jenna M Reinen, Elizabeth W Twamley, Ellen E Lee, Robert P Fellows, Erhan Bilal, Colin A Depp

JMIR Aging 2024;7:e54655

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The Dual Task Ball Balancing Test and Its Association With Cognitive Function: Algorithm Development and Validation

In the presence of disease, for example, a neurodegenerative disease such as Alzheimer disease, cognitive reserve is engaged to sustain function for as long as possible and minimize symptoms and disability. Thus, individuals with more cognitive reserve manifest symptoms or disability later than those with lower cognitive reserve; symptoms are less prominent or severe than might be expected for a given amount of pathology.

Barry Greene, Sean Tobyne, Ali Jannati, Killian McManus, Joyce Gomes Osman, Russell Banks, Ranjit Kher, John Showalter, David Bates, Alvaro Pascual-Leone

J Med Internet Res 2024;26:e49794

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Technology-Enabled Recreation and Leisure Programs and Activities for Older Adults With Cognitive Impairment: Rapid Scoping Review

Adults aged 50 years or older with cognitive impairment including (but not limited to) dementia, Wernicke encephalopathy, delirium, amnestic, Alzheimer disease, organic brain disease or syndrome, benign senescent forgetfulness, Binswanger, Korsakoff syndrome, stroke-related cognitive impairment, Wilhelmsen-Lynch disease, aphasia, Benson syndrome, Huntington's disease, mild cognitive impairment or disorder, Creutzfeldt Jacob disease, or Parkinson disease The populations cannot be at risk for cognitive impairment

Kristina Marie Kokorelias, Josephine McMurray, Charlene Chu, Arlene Astell, Alisa Grigorovich, Pia Kontos, Jessica Babineau, Jessica Bytautas, Ashley Ahuja, Andrea Iaboni

JMIR Neurotech 2024;3:e53038

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The Daily Experiences of Hispanic and Latinx Dementia Caregivers Study: Protocol for a Fully Remote Daily Diary Observational Cohort Study

The prevalence of Alzheimer disease and related dementias (ADRDs) among the Hispanic and Latinx populations is 1.5 times higher than among non-Hispanic White populations [1]. Hispanic and Latinx adults exhibit an earlier onset of ADRDs and more severe symptoms at the time of diagnosis than other ethnic and racial groups [2,3].

Sofía Mildrum Chana, Lorelí Álvarez, Abigail Poe, Natashia Bibriescas, Danny Hai Wang, Stephanie DiFiglia, Andrés Azuero, Michael Crowe, Frank Puga