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The normal tissue–sparing effects of FLASH have been observed in several tissues and animal models, including mouse intestines [19], mouse skin [20], mouse lungs [21], mouse brains [18], and cat and pig skin [22].
Irradiating mouse lungs in vivo, Favaudon et al [21] found that a higher FLASH dose was required to induce radiation pneumonitis and fibrosis than the dose required for conventional radiotherapy (30 Gy for FLASH vs 17 Gy for conventional radiotherapy).
JMIR Res Protoc 2023;12:e41812
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