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Effectiveness of Video Teletherapy in Treating Obsessive-Compulsive Disorder in Children and Adolescents With Exposure and Response Prevention: Retrospective Longitudinal Observational Study

Effectiveness of Video Teletherapy in Treating Obsessive-Compulsive Disorder in Children and Adolescents With Exposure and Response Prevention: Retrospective Longitudinal Observational Study

Obsessive-compulsive disorder (OCD) is a common and often disabling mental health condition that affects 0.25%-4% of children and adolescents [1-3]. Without treatment, OCD can persist into adulthood. Further, it can significantly interfere with a young person's development, education, and relationships. Fortunately, OCD in young people can be effectively managed through psychotherapy, medication, or a combination of the two.

Jamie D Feusner, Nicholas R Farrell, Mia Nunez, Nicholas Lume, Catherine W MacDonald, Patrick B McGrath, Larry Trusky, Stephen Smith, Andreas Rhode

J Med Internet Res 2025;27:e66715

The Effectiveness of a Cell Phone eHealth App in Changing Knowledge, Stigmatizing Attitudes, and Intention to Seek Help Associated With Obsessive-Compulsive Disorder: Pilot Questionnaire Study

The Effectiveness of a Cell Phone eHealth App in Changing Knowledge, Stigmatizing Attitudes, and Intention to Seek Help Associated With Obsessive-Compulsive Disorder: Pilot Questionnaire Study

The game is organized into three different intervention mechanisms: (1) psychoeducation (general information about OCD, OCD heterogeneity, OCD dimensionality, OCD cognitive model, evidence-based treatments, and options for seeking help in OCD), which includes 5 missions, and 1 of them—mission 3—includes a video explaining the OCD cognitive model (1 min); (2) indirect contact (including 6 videos of approximately 2 to 3 minutes of 3 patients diagnosed with OCD who talk about their own experience with OCD: symptom

Antonio Chaves, Sandra Arnáez, Gemma García-Soriano

JMIR Mhealth Uhealth 2024;12:e48027

Effectiveness of One Videoconference-Based Exposure and Response Prevention Session at Home in Adjunction to Inpatient Treatment in Persons With Obsessive-Compulsive Disorder: Nonrandomized Study

Effectiveness of One Videoconference-Based Exposure and Response Prevention Session at Home in Adjunction to Inpatient Treatment in Persons With Obsessive-Compulsive Disorder: Nonrandomized Study

OCD is a common disorder with a lifetime prevalence ranging from 1% to 3% and often has debilitating consequences on the daily functioning, well-being, and quality of life of affected persons as well as family members [4,5]. It usually emerges in late adolescence or early adulthood and has a chronic course if effective treatment is lacking [6,7]. Yet, OCD is often underrecognized and missed in primary care settings [8].

Ulrich Voderholzer, Adrian Meule, Stefan Koch, Simone Pfeuffer, Anna-Lena Netter, Dirk Lehr, Eva Maria Zisler

JMIR Ment Health 2024;11:e52790

Brain Activation During Virtual Reality Symptom Provocation in Obsessive-Compulsive Disorder: Proof-of-Concept Study

Brain Activation During Virtual Reality Symptom Provocation in Obsessive-Compulsive Disorder: Proof-of-Concept Study

Patients with OCD had a mean Y-BOCS score of 23, which indicates moderate symptom severity. All patients had symptoms from multiple OCD dimensions. The most common dominant dimensions included perfectionism or symmetry for 44.4% (n=4) and taboo thoughts (aggressive or sexual intrusions) for 33.3% (n=3) of patients with OCD. Five patients with OCD were treated with a selective serotonin reuptake inhibitor (SSRI) or serotonin and norepinephrine reuptake inhibitor (SNRI), and 4 patients were unmedicated.

Martine J van Bennekom, Guido van Wingen, Willem Benjamin Bruin, Judy Luigjes, Damiaan Denys

JMIR XR Spatial Comput 2024;1:e47468

Predicting Obsessive-Compulsive Disorder Events in Children and Adolescents in the Wild using a Wearable Biosensor (Wrist Angel): Protocol for the Analysis Plan of a Nonrandomized Pilot Study

Predicting Obsessive-Compulsive Disorder Events in Children and Adolescents in the Wild using a Wearable Biosensor (Wrist Angel): Protocol for the Analysis Plan of a Nonrandomized Pilot Study

First-line treatment for OCD is cognitive behavioral therapy with ERP [8,9]. In the context of OCD treatment, ERP refers to approaching OCD symptom–triggering stimuli (exposure) and refraining from performing rituals and compulsions (response prevention). During ERP, patients are asked to intermittently report their level of distress [10]. This information helps the therapist adjust the interventions.

Kristoffer Vinther Olesen, Nicole Nadine Lønfeldt, Sneha Das, Anne Katrine Pagsberg, Line Katrine Harder Clemmensen

JMIR Res Protoc 2023;12:e48571

The Overall Anxiety Severity and Impairment Scale as an Outcome Measure in Internet-Delivered Cognitive Behavioral Therapy for Anxiety Disorders: Observational Study

The Overall Anxiety Severity and Impairment Scale as an Outcome Measure in Internet-Delivered Cognitive Behavioral Therapy for Anxiety Disorders: Observational Study

Efficacious i CBT techniques are available for different ADs, such as generalized anxiety disorder (GAD), panic disorder (PD), and social anxiety disorder (SAD), as well as for disorders with anxiety as a core symptom, for example obsessive-compulsive disorder (OCD) and posttraumatic stress disorder [15,16]. In routine care, conventional CBT and i CBT demonstrate largely similar effectiveness and acceptability profiles [17,18].

Boris Karpov, Jari Olavi Lipsanen, Ville Ritola, Tom Rosenström, Suoma Saarni, Satu Pihlaja, Jan-Henry Stenberg, Paula Laizane, Grigori Joffe

J Med Internet Res 2023;25:e45362

Wearable and Mobile Technologies for the Evaluation and Treatment of Obsessive-Compulsive Disorder: Scoping Review

Wearable and Mobile Technologies for the Evaluation and Treatment of Obsessive-Compulsive Disorder: Scoping Review

The inclusion criteria for study population are as follows: individuals with OCD as the primary diagnosis and of any age and sex. Individuals who did not have OCD as a primary diagnosis were excluded from the study to avoid confounding population factors. We applied no sex or age restrictions because OCD can affect any sex and can develop at any age, including in childhood.

Adam C Frank, Ruibei Li, Bradley S Peterson, Shrikanth S Narayanan

JMIR Ment Health 2023;10:e45572

Memantine for Refractory Obsessive-Compulsive Disorder: Protocol for a Pragmatic, Double-blind, Randomized, Parallel-Group, Placebo-Controlled, Monocenter Trial

Memantine for Refractory Obsessive-Compulsive Disorder: Protocol for a Pragmatic, Double-blind, Randomized, Parallel-Group, Placebo-Controlled, Monocenter Trial

Moreover, both ionotropic glutamate receptors and metabotropic glutamate receptors are linked in virtually every form of learning in the brain, including habit learning [15,29]; are localized in brain circuitry; and are candidates in the pathophysiology of OCD. Several studies show evidence of altered glutamate homeostasis in OCD, with higher levels of glutamate in the cerebrospinal fluid of patients with OCD compared to those of healthy controls [30,31].

Annalisa Maraone, Alessandro Trebbastoni, Antonella Di Vita, Fabrizia D'Antonio, Carlo De Lena, Massimo Pasquini

JMIR Res Protoc 2023;12:e39223