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Quantification of Urinary Exosomal Prostate-Specific Antigen for the Diagnosis of Prostate Cancer Using Clinical Laboratory–Based Techniques: Protocol for a Case-Control Study

Quantification of Urinary Exosomal Prostate-Specific Antigen for the Diagnosis of Prostate Cancer Using Clinical Laboratory–Based Techniques: Protocol for a Case-Control Study

In addition to prostate cancer, other factors can lead to an elevated PSA, including age, prostate infection, and benign prostatic hyperplasia. According to the PSA threshold (usually 4.0 ng/m L), its estimated sensitivity ranges from 67.5% to 80% and its estimated specificity ranges from 60% to 70% [2-4]. Consequently, 20% to 30% of cancers go undetected when only the PSA blood test is considered, and it is not feasible to perform prostate biopsies on a large number of patients.

Guorong Li, Yannick Tholance, Nora Mallouk, Louis Waeckel, Pascale Flandrin, Bruno Bali, Lionel Badet, Pierre Cornillon

JMIR Res Protoc 2024;13:e63551