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In addition to prostate cancer, other factors can lead to an elevated PSA, including age, prostate infection, and benign prostatic hyperplasia. According to the PSA threshold (usually 4.0 ng/m L), its estimated sensitivity ranges from 67.5% to 80% and its estimated specificity ranges from 60% to 70% [2-4]. Consequently, 20% to 30% of cancers go undetected when only the PSA blood test is considered, and it is not feasible to perform prostate biopsies on a large number of patients.
JMIR Res Protoc 2024;13:e63551
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