JMIR Research Protocols

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Dexmedetomidine Versus Midazolam for End-of-Life Sedation and Agitation: Protocol for a Randomized Controlled Trial (The DREAMS Trial)

When targeted symptom management is unsuccessful and patients are distressed, the most appropriate therapy offered may be sedation to relieve these symptoms [2-4] The current standard of care for distress at the end of life includes infused benzodiazepines and antipsychotics, or infused barbiturates in refractory cases [5,6].

Benjamin Thomas, Greg Barclay, Wing-Shan Angela Lo, Judy Mullan, Kylie Mansfield

JMIR Res Protoc 2024;13:e55129

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Illicit Trade of Prescription Medications Through X (Formerly Twitter) in Japan: Cross-Sectional Study

antipsychotics

Hayase Hakariya, Natsuki Yokoyama, Jeonse Lee, Arisa Hakariya, Tatsuki Ikejiri

JMIR Form Res 2024;8:e54023

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Identifying Patterns of Clinical Interest in Clinicians’ Treatment Preferences: Hypothesis-free Data Science Approach to Prioritizing Prescribing Outliers for Clinical Review

Here, we briefly report the successful deployment of one such method (ranking chemicals by kurtosis and a ratio between intercentile differences across all chemical-class pairs) and demonstrate how this identified high prescribing of unusual antipsychotics in 2 small regions of England. We conducted a cross-sectional study using open NHS prescribing data on all dispensed products prescribed by general practices in England, June-August 2017, extracted from the Open Prescribing database.

Brian MacKenna, Helen J Curtis, Lisa E M Hopcroft, Alex J Walker, Richard Croker, Orla Macdonald, Stephen J W Evans, Peter Inglesby, David Evans, Jessica Morley, Sebastian C J Bacon, Ben Goldacre

JMIR Med Inform 2022;10(12):e41200

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Overcoming Decisional Gaps in High-Risk Prescribing by Junior Physicians Using Simulation-Based Training: Protocol for a Randomized Controlled Trial

For example, the use of medications such as antipsychotics, benzodiazepines, and sedative hypnotic “Z-drugs,” to manage delirium and agitation for hospitalized patients remains highly prevalent despite considerable risks associated with their use and guidelines that recommend their avoidance in older adults [12-15]. In this context, there are numerous factors that are stressful for physicians which promote System 1 thinking.

Julie C Lauffenburger, Matthew F DiFrancesco, Renee A Barlev, Ted Robertson, Erin Kim, Maxwell D Coll, Nancy Haff, Constance P Fontanet, Kaitlin Hanken, Rebecca Oran, Jerry Avorn, Niteesh K Choudhry

JMIR Res Protoc 2022;11(4):e31464

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Nonalcoholic Fatty Liver Disease in Children and Adolescents Taking Atypical Antipsychotic Medications: Protocol for a Systematic Review and Meta-analysis

There is an increasing trend in prescribing atypical antipsychotics (AAP) to children and adolescents [1], and this merits a better understanding of their long-term adverse effects. Metabolic complications such as weight gain, hyperlipidemia, and insulin resistance are known side effects of AAP [2-4], and studies have suggested that youngsters are at an increased risk of these side effects compared to older adults [5].

Reem Hatem, Faisal A Nawaz, Ghadah A Al-Sharif, Mohammad Almoosa, Wid Kattan, Christos Tzivinikos, E Lila Amirali, Ammar Albanna