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Fecal calprotectin is a well-established biomarker for inflammatory bowel disease, yet its clinical relevance to other inflammatory diseases remains largely unexplored [10]. Recent studies have shown encouraging results including significant associations with serum calprotectin in patients with spondyloarthritis compared with matched controls and increased serum calprotectin levels correlated with disease activity in both rheumatoid arthritis and axial spondyloarthritis [11,12].
JMIR Res Protoc 2024;13:e62877
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The secondary outcome measure will be biomarkers of gastrointestinal inflammation, as measured by protein concentrations of calprotectin and lipocalin-2 in protein extracts of the stool samples. Furthermore, the microbiota beta diversity, abundance of Bifidobacterium and Lactobacillus, and butyrate production capacity of the gut microbiota will be assessed after each week of treatment. The abundance of Bifidobacterium and Lactobacillus will be determined from the sequencing results.
JMIR Res Protoc 2021;10(10):e29046
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