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Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study

Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study

We applied a novel electroencephalographic-based mobile brain-body imaging approach to measure gait-related brain activation while participants perform complex gait-based functional tasks [11-19]. Raising the complexity of the gait task may allow early distinction of individuals with and without the risk of developing limitations in Cd F by increasing the cognitive demands of the task.

Pierfilippo De Sanctis, Jeannette R Mahoney, Johanna Wagner, Helena M Blumen, Wenzhu Mowrey, Emmeline Ayers, Claudia Schneider, Natasha Orellana, Sophie Molholm, Joe Verghese

JMIR Res Protoc 2024;13:e56726