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Nourishing the Infant Gut Microbiome to Support Immune Health: Protocol of SUN (Seeding Through Feeding) Randomized Controlled Trial

Nourishing the Infant Gut Microbiome to Support Immune Health: Protocol of SUN (Seeding Through Feeding) Randomized Controlled Trial

The infant's immune system and microbiota coevolve throughout the first few months of life, starting a 2-way interaction that eventually leads to competence and maturity [6]. Breast milk and vertical maternal transmission of microorganisms are factors that influence colonization patterns and the immune system's development [1].

Clare R Wall, Nicole C Roy, Jane A Mullaney, Warren Charles McNabb, Olivier Gasser, Karl Fraser, Eric Altermann, Wayne Young, Janine Cooney, Robyn Lawrence, Yannan Jiang, Barbara C Galland, Xiaoxi Fu, Jacqueline N Tonkie, Nisha Mahawar, Amy Luisa Lovell

JMIR Res Protoc 2024;13:e56772

Defining and Risk-Stratifying Immunosuppression (the DESTINIES Study): Protocol for an Electronic Delphi Study

Defining and Risk-Stratifying Immunosuppression (the DESTINIES Study): Protocol for an Electronic Delphi Study

Emerging viral infections in immunocompromised patients: a great challenge to better define the role of immune Reference 9: Pfizer-BioNTech and Oxford AstraZeneca COVID-19 vaccine effectiveness and immune response Reference 10: Immune-mediated adverse events post-COVID vaccination and types of vaccines: a systematic Reference 24: SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive diseaseimmune

Meredith Leston, José Ordóñez-Mena, Mark Joy, Simon de Lusignan, Richard Hobbs, Iain McInnes, Lennard Lee

JMIR Res Protoc 2024;13:e56271

Emerging Trends in Information-Seeking Behavior for Alpha-Gal Syndrome: Infodemiology Study Using Time Series and Content Analysis

Emerging Trends in Information-Seeking Behavior for Alpha-Gal Syndrome: Infodemiology Study Using Time Series and Content Analysis

Alpha-gal syndrome is a type of allergy that is characterized by an immune reaction to the carbohydrate molecule galactose-alpha-1,3-galactose (alpha-gal), which is found in most mammalian or “red meat” [9]. This immune reaction can result in a variety of symptoms including hives, swelling of the face or facial features, shortness of breath, abdominal pain, gastrointestinal issues, anaphylaxis, or even fatality [10].

Jamie L Romeiser, Nicole Jusko, Augusta A Williams

J Med Internet Res 2024;26:e49928

Testing a Model of Care for Patients on Immune Checkpoint Inhibitors Based on Electronic Patient-Reported Outcomes: Protocol for a Randomized Phase II Controlled Trial

Testing a Model of Care for Patients on Immune Checkpoint Inhibitors Based on Electronic Patient-Reported Outcomes: Protocol for a Randomized Phase II Controlled Trial

Immune checkpoint inhibitors (ICIs) have increasingly become part of the standard treatment for multiple cancer types and stages, with the main benefits including superior overall survival rates [1-14]. Although ICIs are generally considered as well-tolerated, they may trigger immune-related adverse events (Ir AEs), which can be severe and result in debilitating or fatal outcomes [15,16].

André Manuel da Silva Lopes, Sara Colomer-Lahiguera, Célia Darnac, Stellio Giacomini, Sébastien Bugeia, Garance Gutknecht, Gilliosa Spurrier-Bernard, Michel Cuendet, Fanny Muet, Veronica Aedo-Lopez, Nuria Mederos, Olivier Michielin, Alfredo Addeo, Sofiya Latifyan, Manuela Eicher

JMIR Res Protoc 2023;12:e48386

Mucocutaneous Manifestations Among HIV-Infected Patients in Madagascar: Cross-Sectional Study

Mucocutaneous Manifestations Among HIV-Infected Patients in Madagascar: Cross-Sectional Study

This finding suggests that the number of mucocutaneous diseases related to HIV infection should be considered among the key clinical indicators for the prediction of underlying immune status and disease progression. Asian and Indian studies have reported similar results [20,21]. Oral candidiasis was found to be the most prevalent infectious dermatoses, associated with a mean CD4 count of 97 cells/mm3.

Fandresena Arilala Sendrasoa, Volatiana Mercia Falimiarintsoa, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja

JMIR Dermatol 2023;6:e47199

Association Between VDR and CYP24A1 Polymorphisms, Atopic Dermatitis, and Biochemical Lipid and Vitamin D Profiles in Spanish Population: Case-Control Study

Association Between VDR and CYP24A1 Polymorphisms, Atopic Dermatitis, and Biochemical Lipid and Vitamin D Profiles in Spanish Population: Case-Control Study

Atopic dermatitis (AD) is the most prevalent inflammatory skin disorder, characterized by impaired epidermal barrier function and an altered immune response; it is caused by a combination of genetic and environmental factors [1-3]. Vitamin D influences both these processes, and several studies have demonstrated an association between 25 OH vitamin D deficiency and AD [4-6], suggesting that vitamin D supplementation may help ameliorate AD severity [7].

Ricardo González-Tarancón, Nuria Goñi-Ros, Elvira Salvador-Rupérez, Ángela Hernández-Martín, Silvia Izquierdo-Álvarez, José Puzo-Foncillas, Yolanda Gilaberte-Calzada

JMIR Dermatol 2023;6:e39567

Public Interest in Immunity and the Justification for Intervention in the Early Stages of the COVID-19 Pandemic: Analysis of Google Trends Data

Public Interest in Immunity and the Justification for Intervention in the Early Stages of the COVID-19 Pandemic: Analysis of Google Trends Data

The spread of infectious diseases has led to increased interest in the human immune system among the public. During a pandemic, the public often becomes interested in how to strengthen their immune systems. Furthermore, the act of purchasing products that may strengthen one’s immune system is popular, even without clear evidence that shows whether these supplements are effective.

Jinhee Lee, Yunna Kwan, Jun Young Lee, Jae Il Shin, Keum Hwa Lee, Sung Hwi Hong, Young Joo Han, Andreas Kronbichler, Lee Smith, Ai Koyanagi, Louis Jacob, SungWon Choi, Ramy Abou Ghayda, Myung-Bae Park

J Med Internet Res 2021;23(6):e26368