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Intravenous Magnesium: Prompt Use for Asthma in Children Treated in the Emergency Department (IMPACT-ED): Protocol for a Multicenter Pilot Randomized Controlled Trial

Intravenous Magnesium: Prompt Use for Asthma in Children Treated in the Emergency Department (IMPACT-ED): Protocol for a Multicenter Pilot Randomized Controlled Trial

To define the optimal dose of IVMg, safety and efficacy outcomes must be correlated with serum concentrations of magnesium in children receiving a range of IVMg doses. Informative pharmacodynamic (PD) analysis requires a marker of respiratory status that can be measured reliably and repeatedly in all patients.

Michael D Johnson, Bradley J Barney, Joseph E Rower, Yaron Finkelstein, Joseph J Zorc

JMIR Res Protoc 2023;12:e48302

Magnesium for the Management of Chronic Noncancer Pain in Adults: Protocol for a Systematic Review

Magnesium for the Management of Chronic Noncancer Pain in Adults: Protocol for a Systematic Review

Magnesium is the fourth most abundant cation in the human body and plays a fundamental role in a variety of physiological processes [16,17]. Magnesium serves as a cofactor in over 300 enzyme systems necessary for regulating blood pressure, protein synthesis, muscle contraction, and blood glucose [18,19]. In the nervous system, magnesium is important for neurotransmission and neuromuscular coordination [20].

Rex Park, Anthony M-H Ho, Gisèle Pickering, Lars Arendt-Nielsen, Mohammed Mohiuddin, Ian Gilron

JMIR Res Protoc 2019;8(1):e11654