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To define the optimal dose of IVMg, safety and efficacy outcomes must be correlated with serum concentrations of magnesium in children receiving a range of IVMg doses.
Informative pharmacodynamic (PD) analysis requires a marker of respiratory status that can be measured reliably and repeatedly in all patients.
JMIR Res Protoc 2023;12:e48302
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Magnesium for the Management of Chronic Noncancer Pain in Adults: Protocol for a Systematic Review
Magnesium is the fourth most abundant cation in the human body and plays a fundamental role in a variety of physiological processes [16,17]. Magnesium serves as a cofactor in over 300 enzyme systems necessary for regulating blood pressure, protein synthesis, muscle contraction, and blood glucose [18,19]. In the nervous system, magnesium is important for neurotransmission and neuromuscular coordination [20].
JMIR Res Protoc 2019;8(1):e11654
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