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In this study, we additionally propose testing the impact of unpredictability (inconsistent caregiver response) on neurodevelopment and psychopathology. We expect unpredictability to have distinct and specific effects on positive valence systems, including ventral striatal function and reward learning.
JMIR Res Protoc 2024;13:e59636
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Until now, most studies evaluating prenatal pesticide exposure and birth outcomes or neurodevelopment have estimated exposure at only 1 or 2 time points during pregnancy [5]. The literature consistently reports that pesticide exposure is associated with adverse health outcomes; however, the actual outcome measure, exposure measures, and even susceptibility measures vary [5].
JMIR Res Protoc 2022;11(2):e31696
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It comes as no surprise that illicit drug use during neurodevelopment is widespread; a quarter (24%) of adolescents (12-17 years) and over half (57%) of emerging adults report illicit drug use in the United States [4]. Moreover, from adolescence to emerging adulthood, lifetime methylenedioxymethamphetamine (MDMA; ecstasy) use surges from 0.8% up to 10.5% and cocaine use rises from 0.7% to 11.4% [4].
JMIR Res Protoc 2020;9(7):e18349
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