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Frontal Pole Neuromodulation for Impulsivity and Suicidality in Veterans With Mild Traumatic Brain Injury and Common Co-Occurring Mental Health Conditions: Protocol for a Pilot Randomized Controlled Trial

Frontal Pole Neuromodulation for Impulsivity and Suicidality in Veterans With Mild Traumatic Brain Injury and Common Co-Occurring Mental Health Conditions: Protocol for a Pilot Randomized Controlled Trial

Mild traumatic brain injury: a type of brain injury resulting from mechanical forces defined by loss of consciousness for Negative urgency impulsivity: a form of impulsivity in which an individual exhibits poor behavioral control or aggression in the setting of a negative event or affect Neuromodulation: a category of brain treatments that modulate or alter neuronal activity through direct electrical or chemical stimulation Transcranial magnetic stimulation: a non-invasive brain treatment that applies a magnetic

Alyssa Bernanke, Rebecca Hasley, Niki Sabetfakhri, Harriet de Wit, Bridget M Smith, Lei Wang, Lisa A Brenner, Colleen Hanlon, Noah S Philip, Olusola Ajilore, Amy Herrold, Alexandra Aaronson

JMIR Res Protoc 2024;13:e58206

Feasibility of a Combined Neuromodulation and Yoga Intervention for Mild Traumatic Brain Injury and Chronic Pain: Protocol for an Open-label Pilot Trial

Feasibility of a Combined Neuromodulation and Yoga Intervention for Mild Traumatic Brain Injury and Chronic Pain: Protocol for an Open-label Pilot Trial

Neuromodulation through transcranial magnetic stimulation (TMS) is another promising noninvasive, nonpharmacological treatment for m TBI+chronic pain. A recent systematic review of repetitive TMS (r TMS) for chronic pain [32] and a meta-analysis of r TMS for neuropathic pain [33] demonstrated that high-frequency r TMS (>1%) applied to the motor cortex effectively reduces pain.

Kelly A Krese, Kyla Z Donnelly, Bella Etingen, Theresa L Bender Pape, Sarmistha Chaudhuri, Alexandra L Aaronson, Rachana P Shah, Dulal K Bhaumik, Andrea Billups, Sabrina Bedo, Mary Terese Wanicek-Squeo, Sonia Bobra, Amy A Herrold

JMIR Res Protoc 2022;11(6):e37836

Cranial Nerve Noninvasive Neuromodulation in Adults With Neurological Conditions: Protocol for a Scoping Review

Cranial Nerve Noninvasive Neuromodulation in Adults With Neurological Conditions: Protocol for a Scoping Review

Cranial nerve noninvasive neuromodulation (CN-NINM) is a novel and emerging technology, grounded in mechanisms that facilitate neuroplasticity, for targeted use in individuals with neurological conditions [7-12]. CN-NINM involves translingual neurostimulation (TLNS) with a portable neuromodulation stimulation (Po NS) device [13-16]. Use of the Po NS device, combined with targeted physical therapy, aims to address longstanding balance and gait deficits in people with neurological conditions [13,14,16].

Keaton Boughen, Tyler Neil, Shayan Dullemond, Kevin Lutowicz, Ahmed Bilgasem, Tyler Hastings, Dina Brooks, Julie Vaughan-Graham

JMIR Res Protoc 2021;10(7):e29965

The Neurostimulation of the Brain in Depression Trial: Protocol for a Randomized Controlled Trial of Transcranial Direct Current Stimulation in Treatment-Resistant Depression

The Neurostimulation of the Brain in Depression Trial: Protocol for a Randomized Controlled Trial of Transcranial Direct Current Stimulation in Treatment-Resistant Depression

Although effective, this method of neuromodulation has several limitations. From a health systems standpoint, it is expensive, time consuming, and resource intensive, requiring the services of a psychiatrist, anesthesiologist, and a variety of acute care allied health staff. As such, only specialized facilities routinely offer ECT, which can limit its utility in rural areas. Moreover, it can exert a deleterious effect on the cognitive function of patients during the course of treatment [10].

Raheem Suleman, Benjamin V Tucker, Serdar M Dursun, Michael L Demas

JMIR Res Protoc 2021;10(3):e22805

Noninvasive Bimodal Neuromodulation for the Treatment of Tinnitus: Protocol for a Second Large-Scale Double-Blind Randomized Clinical Trial to Optimize Stimulation Parameters

Noninvasive Bimodal Neuromodulation for the Treatment of Tinnitus: Protocol for a Second Large-Scale Double-Blind Randomized Clinical Trial to Optimize Stimulation Parameters

Therefore, progression to properly designed, sufficiently powered, blinded, randomized clinical trials are critically needed in the tinnitus field [34,36,57,58] to further confirm the efficacy and safety of bimodal neuromodulation combining sound and cranial nerve stimulation.

Brendan Conlon, Caroline Hamilton, Stephen Hughes, Emma Meade, Deborah A Hall, Sven Vanneste, Berthold Langguth, Hubert H Lim

JMIR Res Protoc 2019;8(9):e13176