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Anxiety related to changes for reasons other than clinical status [26], as well as fear of negative effects, a lack of efficacy, a loss of control, or an increase in side effects [17,26,28], all pave the way for a nocebo effect [28,29]. Clearly, if the physician has gaps in knowledge or biased knowledge, despite a positive attitude toward biosimilars, the chances of a failed switch increase. Therefore, adequate patient communication can help minimize the nocebo effect’s impact.
JMIR Form Res 2024;8:e56553
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In the latter case, this is known as the “nocebo” effect [15]. A communication strategy including reassuring terms, perceived by the brain as agreeable information, can reduce the pain perception. The objective of this strategy is that the painful message becomes less present as much as possible and that the patient benefits from a feeling of control.
JMIR Res Protoc 2023;12:e42043
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Optimized Informed Consent for Psychotherapy: Protocol for a Randomized Controlled Trial
On the other hand, the disclosure of risk information can be harmful in itself, as it might cause nocebo effects. The latter effects are usually described as adverse effects that are not caused by the procedure but by negative expectations or negative prior learning experiences [6,7].
JMIR Res Protoc 2022;11(9):e39843
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