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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection [1]. The progression from infection to sepsis is influenced by both host and pathogen features and, accordingly, is characterized by a high interindividual variability. Sepsis represents a medical emergency, with a strong time dependency, especially for septic shock [2,3]. Therefore, early detection is fundamental to improving the patient outcome by promptly starting treatment.
J Med Internet Res 2025;27:e55492
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These insights can help organ procurement organizations and health care organizations identify areas with low donor registration rates, enabling targeted awareness campaigns to increase participation [26].
Although the application appears to be a promising tool for increasing the reporting of potential donors, it is essential to acknowledge certain limitations that may impact the interpretation of our findings.
JMIR Form Res 2024;8:e50398
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Lessening Organ Dysfunction With Vitamin C (LOVIT) Trial: Statistical Analysis Plan
Sepsis, defined as a dysregulated host immune response to infection that leads to organ dysfunction and death [1], is a major global public health concern, causing up to 5.3 million deaths every year. Current sepsis management is focused on prompt antimicrobial therapy and organ-supportive care, and numerous trials of interventions for immune dysregulation have not demonstrated benefit [2].
JMIR Res Protoc 2022;11(5):e36261
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Safety and Biovigilance in Organ Donation (SAFEBOD): Protocol for a Population-Based Cohort Study
Biovigilance is intended to avoid inadvertent transmission of infectious disease or cancer from organ donors and is a central concern in transplant programs globally. In conflict with these safety concerns is the excess morbidity and mortality experienced by people with end-organ disease on transplant waiting lists. In Australia, increasing the organ donation rate is a national priority. The Australian Government formed the Organ and Tissue Authority (OTA) in 2009.
JMIR Res Protoc 2020;9(10):e18282
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