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Complete Blood Count and Monocyte Distribution Width–Based Machine Learning Algorithms for Sepsis Detection: Multicentric Development and External Validation Study

Complete Blood Count and Monocyte Distribution Width–Based Machine Learning Algorithms for Sepsis Detection: Multicentric Development and External Validation Study

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection [1]. The progression from infection to sepsis is influenced by both host and pathogen features and, accordingly, is characterized by a high interindividual variability. Sepsis represents a medical emergency, with a strong time dependency, especially for septic shock [2,3]. Therefore, early detection is fundamental to improving the patient outcome by promptly starting treatment.

Andrea Campagner, Luisa Agnello, Anna Carobene, Andrea Padoan, Fabio Del Ben, Massimo Locatelli, Mario Plebani, Agostino Ognibene, Maria Lorubbio, Elena De Vecchi, Andrea Cortegiani, Elisa Piva, Donatella Poz, Francesco Curcio, Federico Cabitza, Marcello Ciaccio

J Med Internet Res 2025;27:e55492

Exploring the Potential of an Eye Tissue Donor Reporting App in Enhancing the Procurement of Corneal Donors: Mixed Methods Observational Study

Exploring the Potential of an Eye Tissue Donor Reporting App in Enhancing the Procurement of Corneal Donors: Mixed Methods Observational Study

These insights can help organ procurement organizations and health care organizations identify areas with low donor registration rates, enabling targeted awareness campaigns to increase participation [26]. Although the application appears to be a promising tool for increasing the reporting of potential donors, it is essential to acknowledge certain limitations that may impact the interpretation of our findings.

Dominika Szkodny, Ewa Wróblewska-Czajka, Mikołaj Stryja, Filip Gara, Edward Wylęgała

JMIR Form Res 2024;8:e50398

Safety and Biovigilance in Organ Donation (SAFEBOD): Protocol for a Population-Based Cohort Study

Safety and Biovigilance in Organ Donation (SAFEBOD): Protocol for a Population-Based Cohort Study

Biovigilance is intended to avoid inadvertent transmission of infectious disease or cancer from organ donors and is a central concern in transplant programs globally. In conflict with these safety concerns is the excess morbidity and mortality experienced by people with end-organ disease on transplant waiting lists. In Australia, increasing the organ donation rate is a national priority. The Australian Government formed the Organ and Tissue Authority (OTA) in 2009.

Brenda Rosales, James Hedley, Nicole De La Mata, Claire M Vajdic, Patrick Kelly, Kate Wyburn, Angela C Webster, The SAFEBOD Study Group

JMIR Res Protoc 2020;9(10):e18282