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Patient Acceptability and Technical Reliability of Wearable Devices Used for Monitoring People With Parkinson Disease: Survey Study

Patient Acceptability and Technical Reliability of Wearable Devices Used for Monitoring People With Parkinson Disease: Survey Study

However, the use of patient- and clinician-rated scales is resource-intensive, and the results limited by subjectivity and inaccuracy and are either one-off assessments or dependent on the patient’s recollection [3]. Continuous and accurate assessment of PD features, in both clinical practice and trials, would provide more relevant information and overcome the limitations of clinical scales and questionnaires through real-world data.

Tasmin Alanna Rookes, Amit Batla, Megan Armstrong, Gareth Ambler, Kate Walters, Anette Schrag

JMIR Form Res 2025;9:e63704

Behavioral Therapy–Based Digital Interventions for Treating Osteoarthritis: Systematic Review and Meta-Analysis

Behavioral Therapy–Based Digital Interventions for Treating Osteoarthritis: Systematic Review and Meta-Analysis

Recent patient-centered guideline updates advocate for the implementation of rehabilitation interventions, including exercise therapy and educational programs as recommended nonpharmacological and nonsurgical treatment options [6,7]. These guidelines place a strong emphasis on the role of physical exercise, self-efficacy, and self-management strategies in the rehabilitation process for individuals with OA [8,9].

Beiyao Zhu, Dian Zhu, Xiao'ao Xue, Hongyi Yang, Shurong Zhang

J Med Internet Res 2025;27:e56227

Machine Learning–Based Explainable Automated Nonlinear Computation Scoring System for Health Score and an Application for Prediction of Perioperative Stroke: Retrospective Study

Machine Learning–Based Explainable Automated Nonlinear Computation Scoring System for Health Score and an Application for Prediction of Perioperative Stroke: Retrospective Study

This method has provided a comprehensive understanding of patient risk profiles, but it may not fully capture complex, nonlinear interactions, potentially leading to less accurate risk assessments. Furthermore, the clinical variables incorporated into these systems were typically ascertained through univariate analysis, enriched by insights from expert opinions, or selected from a range of risk factors established in previous literature [8].

Mi-Young Oh, Hee-Soo Kim, Young Mi Jung, Hyung-Chul Lee, Seung-Bo Lee, Seung Mi Lee

J Med Internet Res 2025;27:e58021

Patient and Clinician Perspectives on the Effectiveness of Current Telemedicine Approaches in Endocrinology Care for Type 2 Diabetes: Qualitative Study

Patient and Clinician Perspectives on the Effectiveness of Current Telemedicine Approaches in Endocrinology Care for Type 2 Diabetes: Qualitative Study

Patient participants were recruited from respondents to a previous survey study about telemedicine for T2 D conducted between August 2022 and March 2023. All 24 patient participants contacted for recruitment were adults aged >18 years with T2 D who had used telemedicine in the past year to access endocrinology care at 1 of 7 clinical sites associated with a single large academic medical center. Interviews with clinicians were conducted between June and August 2023.

Margaret Zupa, Megan Hamm, Lane Alexander, Ann-Marie Rosland

JMIR Diabetes 2025;10:e60765

Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

However, rapid up-titration must be balanced with patient safety and tolerability. Sacubitril and valsartan, β-blockers, mineralocorticoid receptor antagonists (MRAs), and SGLT2is are disease-modifying agents that are used as combination therapy and are now regarded as a foundational therapy for HFr EF [1,2]. The conventional approach to initiating and optimizing HFr EF therapy reflects the sequence in which drugs were developed and trialed over the past 40 years [1].

Sumanth Karamchand, Tsungai Chipamaunga, Poobalan Naidoo, Kiolan Naidoo, Virendra Rambiritch, Kevin Ho, Robert Chilton, Kyle McMahon, Rory Leisegang, Hellmuth Weich, Karim Hassan

JMIR Res Protoc 2025;14:e44027

Augmenting Insufficiently Accruing Oncology Clinical Trials Using Generative Models: Validation Study

Augmenting Insufficiently Accruing Oncology Clinical Trials Using Generative Models: Validation Study

RWD can be used for matched controls [18] where patient data from external sources are used instead of recruiting patients to the trial itself. In such a case, previous similar trials, registries, or e Health record datasets on patients under the standard of care are matched to the treatment arm patients, and the matched patients’ data are used as the control arm [19,20]. Such an approach with external controls has been used for running single-arm oncology trials [21,22].

Samer El Kababji, Nicholas Mitsakakis, Elizabeth Jonker, Ana-Alicia Beltran-Bless, Gregory Pond, Lisa Vandermeer, Dhenuka Radhakrishnan, Lucy Mosquera, Alexander Paterson, Lois Shepherd, Bingshu Chen, William Barlow, Julie Gralow, Marie-France Savard, Christian Fesl, Dominik Hlauschek, Marija Balic, Gabriel Rinnerthaler, Richard Greil, Michael Gnant, Mark Clemons, Khaled El Emam

J Med Internet Res 2025;27:e66821

Poststroke eHealth Technologies–Based Rehabilitation for Upper Limb Recovery: Systematic Review

Poststroke eHealth Technologies–Based Rehabilitation for Upper Limb Recovery: Systematic Review

Home-based TR is a branch of telemedicine that consists of the use of a variety of telecommunication platforms (such as telephone visits, mobile apps, serious games, web-based self-care programs, web-based videoconferencing, and sensor-based telemonitoring) by health care professionals to provide necessary patient care and remote evaluation, supervision, and support for persons with disabilities living at home [11,21].

Margherita Rampioni, Sara Leonzi, Luca Antognoli, Anna Mura, Vera Stara

J Med Internet Res 2025;27:e57957

Experiences With an In-Bed Real-Time Motion Monitoring System on a Geriatric Ward: Mixed Methods Study

Experiences With an In-Bed Real-Time Motion Monitoring System on a Geriatric Ward: Mixed Methods Study

Then we know how we have to organize the process or how to do the plan for the patient. In addition, the absence of narratives about specific fall-prevention situations emphasizes that it was not the prevention of falls themselves that played a crucial and relieving role, but rather a sense of safety in relation to falls. Simply knowing that they would be alerted if the patient got up allowed nurses to perform their other activities with less anxiety. Well.

Stefan Walzer, Isabel Schön, Johanna Pfeil, Nicola Merz, Helga Marx, Sven Ziegler, Christophe Kunze

JMIR Form Res 2025;9:e63572

The Utilization of Electronic Consultations (eConsults) to Address Emerging Questions Related to Long COVID-19 in Ontario, Canada: Mixed Methods Analysis

The Utilization of Electronic Consultations (eConsults) to Address Emerging Questions Related to Long COVID-19 in Ontario, Canada: Mixed Methods Analysis

The Ottawa Health Science Network Research Ethics Board waived informed consent for the study due to its retrospective, cross-sectional nature, so individualized patient consent was not obtained. All nonanonymized data were stored on secure servers that are accessible only by approved users who signed a privacy and confidentiality form.

Jatinderpreet Singh, Michael Quon, Danica Goulet, Erin Keely, Clare Liddy

JMIR Hum Factors 2025;12:e58582

Evaluation of the Quality of Delirium Website Content for Patient and Family Education: Cross-Sectional Study

Evaluation of the Quality of Delirium Website Content for Patient and Family Education: Cross-Sectional Study

The literature indicates that not all health care providers engage in this aspect of patient care [26,27]. Time constraints and lack of access to sufficient educational materials limit the ability of health care providers to deliver health education on delirium [28].

Karla Krewulak, Kathryn Strayer, Natalia Jaworska, Krista Spence, Nadine Foster, Scotty Kupsch, Khara Sauro, Kirsten M Fiest

J Med Internet Res 2025;27:e53087